Neurocognitive impairments in non-deprived smokers--results from a population-based multi-center study on smoking-related behavior
| Autor: | Wagner, M., Schulze-Rauschenbach, S., Petrovsky, N., Brinkmeyer, J., von der Goltz, C., Grunder, G., Spreckelmeyer, K., Wienker, T., Diaz-Lacava, A., Mobascher, A., Dahmen, N., Clepce, M., Thuerauf, N., Kiefer, F., de Millas, J., Gallinat, J., Winterer, G. |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Nicotine Alcohol Drinking Adolescent Endophenotypes Neuropsychological Tests epidemiology [Alcohol Drinking] Young Adult Cognition physiopathology [Smoking] Germany Reaction Time Humans Attention Genetic Predisposition to Disease physiology [Verbal Learning] Aged Principal Component Analysis physiopathology [Impulsive Behavior] pharmacology [Nicotine] psychology [Smoking] Smoking Tobacco Use Disorder genetics [Smoking] Verbal Learning Middle Aged Memory Short-Term statistics & numerical data [Neuropsychological Tests] physiology [Memory Short-Term] Case-Control Studies physiopathology [Tobacco Use Disorder] Impulsive Behavior ddc:540 physiology [Attention] drug effects [Cognition] Female genetics [Tobacco Use Disorder] physiology [Reaction Time] psychology [Tobacco Use Disorder] |
| Zdroj: | Addiction biology 18(4), 752-761 (2012). doi:10.1111/j.1369-1600.2011.00429.x Addiction Biology |
| DOI: | 10.1111/j.1369-1600.2011.00429.x |
| Popis: | The aim of the present study was to examine neurocognitive function associated with chronic nicotine use. A total of 2163 healthy participants (1002 smokers, 1161 never-smoking controls) participated in a population-based case-control design. The main outcome measures were six cognitive domain factors derived from a neuropsychological test battery. In smokers, the battery was administered after controlled smoking of one cigarette. Analyses included age, sex and education as covariates. Results demonstrated small, but significant deficits in smokers for visual attention (P < 0.001) and cognitive impulsivity (P < 0.006), while verbal episodic memory, verbal fluency, verbal working memory, and Stroop-interference did not differ between groups. These attention/impulsivity deficits were also present in smokers with only a low amount of cigarette consumption. Lifetime nicotine use (pack-years) was not correlated with cognition in smokers. In conclusion, this study confirmed subtle and specific cognitive deficits in non-deprived smokers. The independence of these deficits from consumption intensity may argue for an a priori deficit of some cognitive abilities in smokers. These specific deficits may constitute intermediate phenotypes for genetic research on nicotine use. |
| Databáze: | OpenAIRE |
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