bFGF Up-regulation reduces spontaneous necrosis of VX2 tumors without increasing tumoral microvascular density
| Autor: | Florentina, Pascale, Saida-Homayra, Ghegediban, Laurent, Bedouet, Julien, Namur, Michel, Bonneau, Valentin, Verret, Isabelle, Schwartz-Cornil, Michel, Wassef, Alex, Laurent |
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| Přispěvatelé: | ProdInra, Migration, ArchimMed, Service de Pathologie, Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Institut National de la Recherche Agronomique (INRA), Unité de recherche Virologie et Immunologie Moléculaires (VIM (UR 0892)), Faculté de médecine, Université Paris Diderot - Paris 7 (UPD7)-Hôpital Louis Mourier - AP-HP [Colombes], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP) |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Neovascularization
Pathologic VX2 [SDV]Life Sciences [q-bio] rabbit experimental tumors VEGF animal models Up-Regulation necrosis [SDV] Life Sciences [q-bio] Liver Neoplasms Experimental clones bFGF transfection Cell Line Tumor plasmid vessel density Microvessels cardiovascular system Animals Fibroblast Growth Factor 2 Rabbits |
| Zdroj: | Anticancer Research Anticancer Research, International Institute of Anticancer Research, 2016, 36 (7), pp.3315-3320 |
| ISSN: | 0250-7005 |
| Popis: | International audience; Aim: To determine whether up-regulation of basic fibroblast growth factor (bFGF) in VX2 cells reduces tumor necrosis. Materials and Methods: VX2 cells were transfected with expression vector containing cDNA of rabbit bFGF. Stable clones producing rabbit bFGF (bFGF-VX2) were selected. bFGF-VX2 (n=5) or non-transfected VX2 (control) (n=5) cells were implanted into leg muscle of 10 rabbits. The tumors were characterized 21 days after grafting. Results: Overexpression of bFGF by VX2 tumors significantly reduced necrosis (p |
| Databáze: | OpenAIRE |
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