| Autor: |
Nt, Mathieu, Genet D, Labrousse F, Philippe Bouillet, Sl, Denes, Martin J, Jl, Labourey, Venat L, Clavere P, Jj, Moreau |
| Rok vydání: |
2004 |
| Předmět: |
|
| Zdroj: |
Europe PubMed Central |
| ISSN: |
0250-7005 |
| Popis: |
The purpose of this work was to determine the response rate and toxicity of a combination of Carmustine and Cisplatin administered before radiation in patients with newly diagnosed high grade astrocytoma. A good response rate has been published with this association in primary cerebral high grade tumor. This protocol was administered in a homogeneous population of 37 adult patients with measurable tumor on magnetic resonance imaging (MRI) or CT scan. After biopsy or subtotal resection, the patients received BCNU 40 mg/m2/d and CODP 40 mg/m2/d, for 3 days every 28 days for 3 cycles. Evaluation was performed before each cycle. Radiation therapy began 4 weeks after completing the chemotherapy or immediately if there was evidence of tumor progression on chemotherapy. Seven out of 37 (19%) demonstrated tumor regression with a median duration to progression of 11 months. Median survival was 6 months. Myelosuppression was the predominant but manageable toxicity. This work indicated that the first chemotherapy protocol gave poor results in a homogeneous group of patients, with bad prognosis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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