| Autor: |
Biava, Mariangela, Fioravanti, Rossella, Porretta, Giulio Cesare, Frachey, G., Mencarelli, Paolo, Sleiter, G., Perazzi, M. E., Simonetti, N., Villa, A. |
| Rok vydání: |
1995 |
| Předmět: |
|
| Zdroj: |
Farmaco (Societa chimica italiana : 1989). 50(6) |
| ISSN: |
0014-827X |
| Popis: |
Owing to the increasing need of drugs for the treatment of a variety of fungal and bacterial opportunistic infections, a study has been started with the aim of synthesizing structures amenable to a number of easily-to-perform structural modifications in order to meet the requirement of bypassing resistance phenomena. This paper reports on the synthesis of several N-(alpha-azaheteroaryl)-substituted 2,5-dimethyl-pyrroles bearing in one beta-position (or in both beta-positions) aminomethyl groups, introduced via a Mannich reaction. Electronic and steric effects by the N-(azaheteroaryl) substituents and the 2- and 5-methyl groups on the course of the Mannich reaction are discussed along with the results of in vitro tests against many Candida species, some bacteria, and several pathogenic plant fungi. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
