The Annexin A1 Receptor FPR2 Regulates the Endosomal Export of Influenza Virus
| Autor: | Fryad Rahman, Mohammad Chebbo, Noémie Courtin, Aurelien Fotso Fotso, Marie-Christine Alessi, Béatrice Riteau |
|---|---|
| Přispěvatelé: | Nutrition, obésité et risque thrombotique (NORT), Aix Marseille Université (AMU)-Institut National de la Recherche Agronomique (INRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre recherche en CardioVasculaire et Nutrition (C2VN), Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), AgenceNationale de la Recherche (ANR HemoFlu to BR), Fondation de France (to BR), Association Vaincre la Mucoviscidose and Gregory LeMarchal (to BR), SATT Sud-Est (to BR) and the Fonds de Recherche en Santé Respiratoire et de la Fondation du Souffle–Formation pour la Recherche 2017, Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN) |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
FPR2
grippe [SDV]Life Sciences [q-bio] viruses Endosomes influenza Annexin A1 Virus Replication Article lcsh:Chemistry Influenza A Virus H1N1 Subtype infection virale Influenza Human Autre (Chimie) métabolisme des peptides Animals Humans maladie infectieuse Receptors Lipoxin lcsh:QH301-705.5 endosome Influenza A Virus H3N2 Subtype Antibodies Monoclonal Receptors Formyl Peptide lcsh:Biology (General) lcsh:QD1-999 A549 Cells anticorps monoclonal anticorps annexine Other |
| Zdroj: | International Journal of Molecular Sciences 5 (19), . (2018) International Journal of Molecular Sciences International Journal of Molecular Sciences, MDPI, 2018, 19 (5), ⟨10.3390/ijms19051400⟩ International Journal of Molecular Sciences, 2018, 19 (5), ⟨10.3390/ijms19051400⟩ International Journal of Molecular Sciences, Vol 19, Iss 5, p 1400 (2018) |
| ISSN: | 1422-0067 1661-6596 |
| DOI: | 10.3390/ijms19051400⟩ |
| Popis: | International audience; The Formyl Peptide Receptor 2 (FPR2) is a novel promising target for the treatment of influenza. During viral infection, FPR2 is activated by annexinA1, which is present in the envelope of influenza viruses; this activation promotes virus replication. Here, we investigated whether blockage of FPR2 would affect the genome trafficking of influenza virus. We found that, upon infection and cell treatment with the specific FPR2 antagonist WRW4 or the anti-FPR2 monoclonal antibody, FN-1D6-AI, influenza viruses were blocked into endosomes. This effect was independent on the strain and was observed for H1N1 and H3N2 viruses. In addition, blocking FPR2signaling in alveolar lung A549 epithelial cells with the monoclonal anti-FPR2 antibody significantly inhibited virus replication. Altogether, these results show that FPR2signaling interferes with the endosomal trafficking of influenza viruses and provides, for the first time, the proof of concept that monoclonal antibodies directed against FPR2 inhibit virus replication. Antibodies-based therapeutics have emerged as attractive reagents in infectious diseases. Thus, this study suggests that the use of anti-FPR2 antibodies against influenza hold great promise for the future. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|