[Bacterial infections as seen from the eukaryotic genome: DNA double strand breaks, inflammation and cancer]
| Autor: | Claudie, Lemercier |
|---|---|
| Přispěvatelé: | Lemercier, Claudie, Laboratoire de Biologie à Grande Échelle (BGE - UMR S1038), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), INSERM, Université Grenoble Alpes, CEA, Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]) |
| Jazyk: | francouzština |
| Rok vydání: | 2014 |
| Předmět: |
Inflammation
bactérie Genome DNA Repair Helicobacter pylori génome Bacterial Infections cassure de l'ADN infection Eukaryotic Cells [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases Neoplasms Escherichia coli [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases Animals Humans cancer DNA Breaks Double-Stranded |
| Zdroj: | médecine/sciences médecine/sciences, 2014, 30 (8-9), pp.758-64. ⟨10.1051/medsci/20143008013⟩ médecine/sciences, EDP Sciences, 2014, 30 (8-9), pp.758-64. ⟨10.1051/medsci/20143008013⟩ |
| ISSN: | 0767-0974 1958-5381 |
| DOI: | 10.1051/medsci/20143008013 |
| Popis: | International audience; An increasing number of studies report that infection by pathogenic bacteria alters the host genome, producing highly hazardous DNA double strand breaks for the eukaryotic cell. Even when DNA repair occurs, it often leaves "scars" on chromosomes that might generate genomic instability at the next cell division. Chronic intestinal inflammation promotes the expansion of genotoxic bacteria in the intestinal microbiote which in turn triggers tumor formation and colon carcinomas. Bacteria act at the level of the host DNA repair machinery. They also highjack the host cell cycle to allow themselves time for replication in an appropriate reservoir. However, except in the case of bacteria carrying the CDT nuclease, the molecular mechanisms responsible for DNA lesions are not well understood, even if reactive oxygen species released during infection make good candidates. |
| Databáze: | OpenAIRE |
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