Vertebral Bone Marrow Fat Is independently Associated to VAT but Not to SAT: KORA FF4—Whole-Body MR Imaging in a Population-Based Cohort
| Autor: | Dunja, Hasic, Roberto, Lorbeer, Robert C, Bertheau, Jürgen, Machann, Susanne, Rospleszcz, Johanna, Nattenmüller, Wolfgang, Rathmann, Annette, Peters, Fabian, Bamberg, Christopher L, Schlett |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male subcutaneous adipose tissue bone marrow Subcutaneous Fat lcsh:TX341-641 Intra-Abdominal Fat Article Cohort Studies Metabolic Diseases Risk Factors Humans magnetic resonance imaging Whole Body Imaging visceral adipose tissue Exercise Adiposity Aged Glycated Hemoglobin Age Factors Middle Aged metabolic disease Lipids Spine Heart Disease Risk Factors Linear Models Female lcsh:Nutrition. Foods and food supply |
| Zdroj: | Nutrients, Vol 12, Iss 1527, p 1527 (2020) Nutrients Volume 12 Issue 5 |
| ISSN: | 2072-6643 |
| Popis: | The objective of the current study was to assess the relationship of bone marrow adipose tissue (BMAT) content to abdominal fat depots, including visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT), as well as cardiovascular risk factors (CVRF) beyond physical activity in a population-based cohort study undergoing whole-body magnetic resonance (MR) imaging. Subjects of the Cooperative Health Research in the Augsburg Region (KORA) FF4 study without known cardiovascular disease underwent fat fraction quantification in vertebrae (BMATL1/L2) via a 2-point T1-weighted volumetric interpolated breath-hold examination (VIBE) Dixon sequence. The same MR sequence was applied to quantify VAT and SAT volume. Subjects&rsquo characteristics, including physical activity, were determined through standardized exams and self-assessment questionnaires. Univariate and multivariate linear regression were applied. In the cohort of 378 subjects (56 ± 9.1years 42.1% female), BMATL1/L2 was 54.3 ± 10.1%, VAT was 4.54 ± 2.71 L, and SAT was 8.10 ± 3.68 L. VAT differed significantly across BMATL1/L2 tertiles (3.60 ± 2.76 vs. 4.92 ± 2.66 vs. 5.11 ± 2.48 p < 0.001), there was no significant differences for SAT (p = 0.39). In the fully adjusted model, VAT remained positively associated with BMATL1/L2 (&beta = 0.53, p = 0.03). Furthermore, BMATL1/L2 was associated with age (&beta = 5.40 per 10-years, p < 0.001), hemoglobin A1c (HbA1c &beta = 1.55 per 1%, p = 0.04), lipids (&beta = 0.20 per 10 mg/dL triglycerides = 0.40 per 10 mg/dL low-density lipoprotein (LDL) =&minus 3.21 lipid-lowering medication all p < 0.05), and less physical activity (&beta = 3.7 &ldquo no or nearly no exercise&rdquo as compared to &ldquo &ge 2 h per week, regularly&rdquo p = 0.003) gender was not significantly different (p = 0.57). In the population-based cohort, VAT but not SAT were associated with higher BMATL1/L2 independently of physical activity and other cardiovascular risk factors. Further, BMATL1/L2 increased with older age, less physical activity, higher HbA1c, and increased lipids but decreased with lipid-lowering medication. |
| Databáze: | OpenAIRE |
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