Astrovirus and digestive disorders in neonatal units
| Autor: | Chappé, Céline, Minjolle, Sophie, Dabadie, Alain, Morel, Laetitia, Colimon, Ronald, Pladys, Patrick |
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| Přispěvatelé: | Service de Pédiatrie, Hôpital Pontchaillou-CHU Pontchaillou [Rennes], Laboratoire de Virologie [Rennes] = Virology [Rennes], CHU Pontchaillou [Rennes], Service de virologie, Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-CHU Pontchaillou [Rennes] |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Male
MESH: Nurseries Hospital Astrovirus Feces fluids and secretions MESH: Astroviridae Infections Necrotizing enterocolitis Astroviridae Infections Intensive Care Units Neonatal Humans Retrospective Studies Bloody stool Newborns [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics MESH: Humans MESH: Infant Newborn Infant Newborn Preterm infants MESH: Feces MESH: Retrospective Studies MESH: Male Nurseries Hospital MESH: Mamastrovirus [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology Female [SDV.IB]Life Sciences [q-bio]/Bioengineering MESH: Female MESH: Intensive Care Units Neonatal Mamastrovirus |
| Zdroj: | Acta Paediatrica Acta Paediatrica, Wiley, 2012, 101 (5), pp.e208-12. ⟨10.1111/j.1651-2227.2011.02569.x⟩ |
| ISSN: | 2005-2006 0803-5253 |
| DOI: | 10.1111/j.1651-2227.2011.02569.x⟩ |
| Popis: | International audience; AIM: To describe clinical signs associated with Human Astrovirus (HAstV) in stools in neonatal units. METHODS: During 2005-2006, all stool virology performed for isolated digestive symptoms or suspicion of neonatal infection was tested for HAstV by an amplified enzyme-linked immunoassay (IDEIA™ Astrovirus test, Dako Cytomation). Each newborn with a positive result (HAstV+ group) was retrospectively matched with the first following symptomatic newborn in the same care unit having a negative stool virology (HAstV- group). Clinical data were collected during two 3-day periods (just after faecal samples collection and 1 week before) and compared within and between each group. RESULTS: Human astrovirus was detected in faeces of 68 newborns [gestational age: 31.4(28.8-34) weeks] at a post-natal age of 23 (15-42) days without seasonal dominance. Human astrovirus+ and HAstV- groups were comparable. Bloody stool (54.4% versus 14.7%, p < 0.01) and stage II-III necrotizing enterocolitis (20.6% versus 4.4%, p < 0.05) were more frequently observed in HAstV+ than in HAstV- group; these associations were confirmed by logistic regression analysis. CONCLUSION: This descriptive study argues for a possible association between HAstV and digestive symptoms in newborns specifically in preterm infants. |
| Databáze: | OpenAIRE |
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