[New approaches to construction of transgenic animals with high level tissue-specific expression of foreign genes: construction and reconstruction of genomic domains]

Autor:	Sergey Razin, Lv, Verbovaia, Il, Gol Dman
Rok vydání:	2000
Předmět:	Animals Genetically Modified Enhancer Elements Genetic Eukaryotic Cells Genome Gene Transfer Techniques Animals Gene Expression Humans Transgenes Locus Control Region Promoter Regions Genetic Introns
Zdroj:	Europe PubMed Central
ISSN:	0016-6758
Popis:	The major problems in constructing transgenic animals and approaches to their solution are discussed. Modern views of the structural-functional organization of the eukaryotic genome are considered. The domain hypothesis of the genome organization is analyzed in detail, as many problems associated with a low level and a lack of tissue specificity of transgene expression can be solved at the step of construction (or reconstruction of existing domains).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::9f4b697038e7de22cecadbaa8dafd0f6 https://pubmed.ncbi.nlm.nih.gov/11094761 Zobrazit plný text záznamu