[C-erbB-2 oncogene amplification in breast cancer in correlation to steroid and epidermal growth factor receptor]

Autor:	Manavi M, Kf, Czerwenka, Robert Zeillinger, Speiser P, Kury F, Steinhart U, Peschke M, Kubista E, Reinold E
Jazyk:	němčina
Rok vydání:	1992
Předmět:	Receptor ErbB-2 Gene Amplification Breast Neoplasms ErbB Receptors Immunoenzyme Techniques Carcinoma Intraductal Noninfiltrating Receptors Estrogen Lymphatic Metastasis Proto-Oncogene Proteins Biomarkers Tumor Humans Female Breast Lymph Nodes Receptors Progesterone Neoplasm Staging
Zdroj:	Europe PubMed Central
ISSN:	0044-4197
Popis:	The amplification grade of oncogene c-erbB-2 was examined by the polymerase-chain-reaction-method in DNA's of 56 primary mammary carcinomas. 26 (46.4%) of these showed the amplified oncogene c-erbB-2. In the strongly amplified cases, the expression of the c-erbB-2 oncoprotein was verifiable immunohistochemically. Between the progesterone receptor status (PR) and the amplified c-erbB-2 oncogene there was a statistically proven dependency. No correlation was observed between the amplified c-erbB-2 oncogene and the epidermal growth-factor receptor (EGFR).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::9ea70bc25f86b404ba1f0cbb197d4ca0 https://pubmed.ncbi.nlm.nih.gov/1350129 Zobrazit plný text záznamu