Health-Related Quality of Life according to Renal Function: Results from a Nationwide Health Interview and Examination Survey
| Autor: | Liv, Faulhaber, Stefan, Herget-Rosenthal, Hannes, Jacobs, Falk, Hoffmann |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male glomerular filtration rate Short form health Survey-36 Glomerular filtration rate Health-related quality of life Chronic kidney disease short form health survey-36 Dermatology Middle Aged Kidney Diseases of the genitourinary system. Urology health-related quality of life Germany Surveys and Questionnaires RL1-803 RC666-701 Quality of Life Humans Diseases of the circulatory (Cardiovascular) system Female RC870-923 Renal Insufficiency Chronic chronic kidney disease Aged Research Article |
| Zdroj: | Kidney & Blood Pressure Research, Pp 1-10 (2021) Kidney & blood pressure research, 47(1):13-22 Kidney Blood Press Res |
| Popis: | Most studies on health-related quality of life (HRQoL) in chronic kidney disease (CKD) focus on patients with end-stage kidney disease although they represent a small proportion of patients with CKD. We aimed to analyze HRQoL according to glomerular filtration rate (GFR) categories in a population-based sample of adults living in Germany. Methods: Data from the German health interview and examination survey conducted from 2008 to 2011 were used. Participants with valid interview and examination data aged 40–79 years were included (n = 5,159). Serum creatinine levels were used to calculate estimated GFR via the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. We classified kidney function in GFR categories according to the Kidney Disease Improving Global Outcomes Initiative (KDIGO) guidelines on CKD: G1 (high): ≥90 mL/min/1.73 m2, G2 (normal): 60–89 mL/min/1.73 m2, G3a (mildly decreased): 45–59 mL/min/1.73 m2, G3b (moderately decreased): 30–44 mL/min/1.73 m2, G4/5 (severely decreased/end-stage kidney disease): 2. HRQoL was evaluated with the Short Form Health Survey (SF-36). Different multivariate linear and logistic regression models were used to analyze the association of HRQoL with GFR categories. Results: Overall, 5.9% had a GFR 2 (corresponding to categories G3a, G3b, and G4/5). Compared to category G2 linear regression showed a decline in physical HRQoL in categories G3a (−2.34, p = 0.004), G3b (−5.37, p = 0.009), and G4/5 (−4.82, p = 0.117). No decline in mental HRQoL was detected with increasing GFR categories. Categories G3a to G4/5 were significantly associated with a low perceived general state of health (G3a: odds ratio [OR] = 2.03, p = 0.001; G3b: OR = 3.01, p = 0.009; G4/5: OR = 8.70, p = 0.016) when compared to category G2. Conclusion: In a representative sample of adults living in Germany, both physical HRQoL and the perceived general state of health are already significantly reduced in category G3a. |
| Databáze: | OpenAIRE |
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