Synthesis and Characterization of Nanofunctionalized Gelatin Methacrylate Hydrogels
| Autor: | Rahali, Kamel, Ben Messaoud, Ghazi, Kahn, Cyril, Sanchez-Gonzalez, Laura, Kaci, Mouna, CLEYMAND, Franck, Fleutot, Solenne, Linder, Michel, Desobry, Stéphane, Arab-Tehrany, Elmira |
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| Přispěvatelé: | Laboratoire d'Ingénierie des Biomolécules (LIBio), Université de Lorraine (UL), Institut Jean Lamour (IJL), Université de Lorraine (UL)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie du CNRS (INC)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
MESH: Gelatin/chemistry*
Hydrogels/chemical synthesis* Hydrogels/chemistry Methacrylates/chemistry [SDV.BIO]Life Sciences [q-bio]/Biotechnology Surface Properties nanoliposome nanoemulsion Biocompatible Materials mechanical properties Article lcsh:Chemistry functionalized hydrogel LF/HF ultrasounds Materials Testing Spectroscopy Fourier Transform Infrared [SDV.IB.BIO]Life Sciences [q-bio]/Bioengineering/Biomaterials lcsh:QH301-705.5 GelMA Tissue Scaffolds Hydrogels [CHIM.MATE]Chemical Sciences/Material chemistry [CHIM.POLY]Chemical Sciences/Polymers lcsh:Biology (General) lcsh:QD1-999 tissue engineering MESH: Tissue Engineering/methods Tissue Scaffolds/chemistry Microscopy Electron Scanning Gelatin Methacrylates Nanoparticles MESH: Biocompatible Materials/chemical synthesis Biocompatible Materials/chemistry MESH: Nanoparticles |
| Zdroj: | International Journal of Molecular Sciences, Vol 18, Iss 12, p 2675 (2017) International Journal of Molecular Sciences International Journal of Molecular Sciences, MDPI, 2017, 18 (12), pp.2675. ⟨10.3390/ijms18122675⟩ |
| ISSN: | 1422-0067 1661-6596 |
| DOI: | 10.3390/ijms18122675⟩ |
| Popis: | International audience; Given the importance of the extracellular medium during tissue formation, it was wise to develop an artificial structure that mimics the extracellular matrix while having improved physico-chemical properties. That is why the choice was focused on gelatin methacryloyl (GelMA), an inexpensive biocompatible hydrogel. Physicochemical and mechanical properties were improved by the incorporation of nanoparticles developed from two innovative fabrication processes: High shear fluid and low frequencies/high frequencies ultrasounds. Both rapeseed nanoliposomes and nanodroplets were successfully incorporated in the GelMA networks during the photo polymerization process. The impact on polymer microstructure was investigated by Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and enzymatic degradation investigations. Mechanical stability and viscoelastic tests were conducted to demonstrate the beneficial effect of the functionalization on GelMA hydrogels. Adding nanoparticles to GelMA improved the surface properties (porosity), tuned swelling, and degradability properties. In addition, we observed that nanoemulsion didn't change significantly the mechanical properties to shear and compression solicitations, whereas nanoliposome addition decreased Young's modulus under compression solicitations. Thus, these ways of functionalization allow controlling the design of the material by choosing the type of nanoparticle (nanoliposome or nanoemulsion) in function of the application. |
| Databáze: | OpenAIRE |
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