The effects of terlipressin and direct portacaval shunting on liver hemodynamics following 80% hepatectomy in the pig
| Autor: | Hammond, John S., Godtliebsen, Fred, Steigen, Sonja, Guha, I. Neil, Wyatt, Judy, Revhaug, Arthur, Lobo, Dileep N., Mortensen, Kim E. |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
Portacaval Shunt Surgical Portal Vein Sus scrofa portacaval shunt VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Gastroenterology: 773 Portal Pressure terlipressin Disease Models Animal Hepatic Artery Liver VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Gasteroenterologi: 773 Animals Hepatectomy post-resection liver failure Research Articles Blood Flow Velocity Liver Failure Research Article Liver Circulation |
| Zdroj: | Clinical Science (London, England : 1979) |
| ISSN: | 0143-5221 1470-8736 |
| Popis: | Liver failure is the major cause of death following liver resection. Post-resection portal venous pressure (PVP) predicts liver failure, is implicated in its pathogenesis, and when PVP is reduced, rates of liver dysfunction decrease. The aim of the present study was to characterize the hemodynamic, biochemical, and histological changes induced by 80% hepatectomy in non-cirrhotic pigs and determine if terlipressin or direct portacaval shunting can modulate these effects. Pigs were randomized (n=8/group) to undergo 80% hepatectomy alone (control); terlipressin (2 mg bolus + 0.5–1 mg/h) + 80% hepatectomy; or portacaval shunt (PCS) + 80% hepatectomy, and were maintained under terminal anesthesia for 8 h. The primary outcome was changed in PVP. Secondary outcomes included portal venous flow (PVF), hepatic arterial flow (HAF), and biochemical and histological markers of liver injury. Hepatectomy increased PVP (9.3 ± 0.4 mmHg pre-hepatectomy compared with 13.0 ± 0.8 mmHg post-hepatectomy, P |
| Databáze: | OpenAIRE |
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