Interreader agreement of PI-RADS v. 2 in assessing prostate cancer with multiparametric MRI: A study using whole-mount histology as the standard of reference
| Autor: | Girometti, R., Giannarini, G., Greco, F., Isola, M., Cereser, L., Como, G., Sioletic, S., Pizzolitto, S., Crestani, A., Ficarra, V., Zuiani, C. |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
Observer Variation Prostatectomy interobserver variability Biopsy Prostate Prostatic Neoplasms Reproducibility of Results Seminal Vesicles Middle Aged Reference Standards prostatic neoplasms magnetic resonance imaging interobserver variability magnetic resonance imaging prostatic neoplasms Image Processing Computer-Assisted Humans Prospective Studies Multiparametric Magnetic Resonance Imaging Radiology Algorithms Aged |
| Popis: | Most studies assessing interreader agreement of Prostate Imaging Reporting and Data System v. 2 (PI-RADS v2) have used biopsy as the standard of reference, thus carrying the risk of not definitively noting all existent cancers.To evaluate the interreader agreement in assessing prostate cancer (PCa) of PI-RADS v2, using whole-mount histology as the standard of reference.Monocentric prospective cohort study.In all, 48 patients with biopsy-proven PCa referred for radical prostatectomy, undergoing staging multiparametric magnetic resonance imaging (mpMRI) between May 2016 to February 2017.3.0T system using high-resolution TCohen's kappa analysis of agreement.On 71 lesions found on histology, there was moderate agreement in assigning PI-RADS categories to all cancers (k = 0.53) and clinically significant cancers (csPCa) (k = 0.47). Assessing csPCa with PI-RADS ≥4 cutoff provided higher agreement than PI-RADS ≥3 cutoff (k = 0.63 vs. 0.57). Interreader agreement was higher between more experienced readers, with the most experienced one achieving the highest cancer detection rate (0.73 for csPCa using category ≥4). There was substantial agreement in assessing stage ≥pT3 (k = 0.72).We found moderate to substantial agreement in assigning the PI-RADS v2 categories and assessing the spectrum of cancers found on whole-mount histology, with category 4 as the most reproducible cutoff for csPCa. Readers' experience influenced interreader agreement and cancer detection rate.2 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2019;49:546-555. |
| Databáze: | OpenAIRE |
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