Scatter Factor Receptor (c-Met) as Possible Prognostic Factor in Patients with Oral Squamous Cell Carcinoma
| Autor: | Lo Muzio, L., Leonardi, R., Mignogna, M. D., Pannone, G., Rubini, C., Pieramici, T., Trevisiol, L., Ferrari, F., Rosario SERPICO, Testa, N., Rosa, G., Staibano, S. |
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| Přispěvatelé: | Lo Muzio, L, Leonardi, R, Mignogna, MICHELE DAVIDE, Pannone, G, Rubini, C, Pieramici, T, Trevisiol, L, Ferrari, F, Serpico, R, Testa, N, DE ROSA, Gaetano, Staibano, Stefania |
| Předmět: |
Adult
Male enzymology/metabolism Mouth Neoplasm biosynthesis Stromal Cell Vascular Biomarkers Tumor 80 and over Carcinoma Humans metabolism Female Humans Immunohistochemistry Lymphatic Metastasis Male Middle Aged Mouth Mucosa Aged Neoplasm Staging Aged 80 and over Mouth Mucosa enzymology/metabolism/pathology Endothelium Middle Aged Proto-Oncogene Proteins c-met Prognosis Biological Immunohistochemistry Adult Aged Aged Squamous Cell Lymphatic Metastasis Carcinoma Squamous Cell Female Mouth Neoplasms Endothelium Vascular metabolism Tumor Marker Stromal Cells biosynthesis enzymology/metabolism/pathology Neoplasm Staging Prognosis Proto-Oncogene Proteins c-met |
| Zdroj: | Scopus-Elsevier Publons |
| Popis: | This report was performed to study the biological role of c-Met in oral tumorigenesis by analyzing its expression in relation to clinicopathological features. Seventy-three cases of oral squamous cell carcinoma and 10 of normal mucosa were analysed for c-Met expression by immunohistochemistry. Normal oral squamous epithelium showed absent or low membranous positivity in the intermediate (malpighian-spinous) layer. Fifty-seven cases (78\%) of carcinoma showed immunopositivity, with a prevalently membranous positivity and scattered areas also showing a cytoplasmic localization. Sixteen cases of carcinoma (22\%) showed no positivity for c-Met. Among positive tumours, well-differentiated areas showed low or absent cytoplasmic positivity, while low-differentiated areas showed both membranous and cytoplasmic positivity. There was no statistically significant correlation between c-Met expression and sex, recurrence, staging or grading. The frequency of lymph node metastases was higher in c-Met-positive tumours (17/57, 29\%) than in c-Met-negative ones (4/16, 25\%). When analysed for prognostic significance, patients with negative/reduced c-Met expression had better survival rates than patients with high expression. The difference between survival rates was statistically significant (p |
| Databáze: | OpenAIRE |
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