ACE2 polymorphism and susceptibility for SARS-CoV-2 infection and severity of COVID-19
| Autor: | Möhlendick, Birte, Schönfelder, Kristina, Breuckmann, Katharina, Elsner, Carina, Babel, Nina, Balfanz, Paul, Dahl, Edgar, Dreher, Michael, Fistera, David, Herbstreit, Frank, Hölzer, Bodo, Koch, Michael, Kohnle, Matthias, Marx, Nikolaus, Risse, Joachim, Schmidt, Karsten, Skrzypczyk, Sarah, Sutharsan, Sivagurunathan, Taube, Christian, Westhoff, Timm H, Jöckel, Karl-Heinz, Dittmer, Ulf, Siffert, Winfried, Kribben, Andreas |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Adolescent Genotype rs2285666 Medizinische Fakultät » Universitätsklinikum Essen » Ruhrlandklinik Essen – Universitätsklinik viruses Medizin ACE2 Polymorphism Single Nucleotide Severity of Illness Index Young Adult coronavirus disease 2019 Medizinische Fakultät » Universitätsklinikum Essen » Klinik für Nephrologie Risk Factors Humans Genetic Predisposition to Disease ddc:610 skin and connective tissue diseases Medizinische Fakultät » Universitätsklinikum Essen » Institut für Medizinische Informatik Biometrie und Epidemiologie Aged Aged 80 and over fungi virus diseases COVID-19 Original Articles Medizinische Fakultät » Universitätsklinikum Essen » Institut für Virologie Middle Aged single-nucleotide polymorphism body regions Medizinische Fakultät » Universitätsklinikum Essen » Zentrum für Notfallmedizin Medizinische Fakultät » Universitätsklinikum Essen » Institut für Pharmakogenetik Medizinische Fakultät » Universitätsklinikum Essen » Institut für Diagnostische und Interventionelle Radiologie und Neuroradiologie ComputingMethodologies_DOCUMENTANDTEXTPROCESSING Female Angiotensin-Converting Enzyme 2 Medizinische Fakultät » Universitätsklinikum Essen » Klinik für Anästhesiologie und Intensivmedizin severe acute respiratory syndrome coronavirus 2 |
| Zdroj: | Pharmacogenetics and Genomics |
| ISSN: | 1744-6880 |
| Popis: | Supplemental Digital Content is available in the text. Objectives The RNA virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for coronavirus disease 2019 (COVID-19). Cell entry is mediated by the human angiotensin-converting enzyme II (ACE2). ACE2 and its close homolog angiotensin-converting enzyme I (ACE) are currently discussed candidate genes, in which single-nucleotide polymorphisms (SNPs) could alter binding or entry of SARS-CoV-2 and enhance tissue damage in the lung or other organs. This could increase the susceptibility for SARS-CoV-2 infection and the severity of COVID-19. Patients and methods We performed genotyping of SNPs in the genes ACE2 and ACE in 297 SARS-CoV-2-positive and 253 SARS-CoV-2-negative tested patients. We analyzed the association of the SNPs with susceptibility for SARS-CoV-2 infection and the severity of COVID-19. Results SARS-CoV-2-positive and SARS-CoV-2-negative patients did not differ regarding demographics and clinical characteristics. For ACE2 rs2285666, the GG genotype or G-allele was significantly associated with an almost two-fold increased SARS-CoV-2 infection risk and a three-fold increased risk to develop serious disease or COVID-19 fatality. In contrast, the ACE polymorphism was not related to infection risk or severity of disease. In a multivariable analysis, the ACE2 rs2285666 G-allele remained as an independent risk factor for serious disease besides the known risk factors male gender and cardiovascular disease. Conclusions In summary, our report appears to be the first showing that a common ACE2 polymorphism impacts the risk for SARS-CoV-2 infection and the course of COVID-19 independently from previously described risk factors. |
| Databáze: | OpenAIRE |
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