Light-dependant intraretinal ion regulation by melanopsin in young awake and free moving mice evaluated with manganese-enhanced MRI

Autor:	Berkowitz, B. A., Roberts, R., David Bissig
Rok vydání:	2010
Předmět:	Ions Aging Manganese Light Movement Rod Opsins Darkness Magnetic Resonance Imaging Retina Mice Inbred C57BL Mice Animals sense organs Wakefulness Research Article
Zdroj:	Molecular Vision Scopus-Elsevier Europe PubMed Central David Bissig
ISSN:	1090-0535
Popis:	Purpose To test the hypothesis that in young, functionally blind mice, light-dependent intraretinal ion regulation occurs via melanopsin. Methods Postnatal day (P) 7 wild type (WT, C57Bl/6) and melanopsin knockout (KO, opn4−/−, B6129) mice were light or dark adapted. Awake and freely moving animals were injected intraperitoneally (ip) with MnCl2. Four hours later, the mice in both groups were anesthetized and studied with manganese-enhanced MRI (MEMRI) to measure the extent of intraretinal uptake of manganese and whole retinal thicknesses. Results In control P7 mice, light exposure increased (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::976aac359069844b616c00adcee36af3 https://pubmed.ncbi.nlm.nih.gov/20808732 Zobrazit plný text záznamu