Structural Features Defining NF-κB Inhibition by Lignan-Inspired Benzofurans and Benzothiophenes

Autor:	Dao-Huy, Toan, Latkolik, Simone, Bräuer, Julia, Pfeil, Andreas, Stuppner, Hermann, Schnürch, Michael, Dirsch, Verena M., Mihovilovic, Marko D.
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	natural product direct arylation lcsh:QR1-502 Anti-Inflammatory Agents NF-kappa B lignans Thiophenes lcsh:Microbiology Article Structure-Activity Relationship HEK293 Cells mental disorders cross-coupling Humans NF-κB inhibition C-H activation Benzofurans
Zdroj:	Biomolecules Volume 10 Issue 8 Biomolecules, Vol 10, Iss 1131, p 1131 (2020)
ISSN:	2218-273X
DOI:	10.3390/biom10081131
Popis:	A series of 2-arylbenzofurans and 2-arylbenzothiophenes was synthesized carrying three different side chains in position five. The synthesized compounds were tested for NF-&kappa B inhibition to establish a structure activity relationship. It was found that both, the side chain in position five and the substitution pattern of the aryl moiety in position two have a significant influence on the inhibitory activity.
Databáze:	OpenAIRE
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