Biomarkers for the management of pre-eclampsia in pregnant women
| Autor: | Lakshmi Tanuja Petla, Rosy Chikkala, K S Ratnakar, Vijayalakshmi Kodati, V Sritharan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Vascular Endothelial Growth Factor A
pre-eclampsia placenta Galectins lcsh:Medicine Receptors Cell Surface Review Article Pregnancy Proteins Lipocalin-2 Antigens CD Pregnancy Risk Factors Proto-Oncogene Proteins Humans Pregnancy-Associated Plasma Protein-A NGAL Angiogenic factors Vascular Endothelial Growth Factor Receptor-1 lcsh:R Endoglin biomarkers Lipocalins Angiogenic factors - biomarkers - NGAL - pre-eclampsia - placenta - proteinuria Female proteinuria Acute-Phase Proteins |
| Zdroj: | The Indian Journal of Medical Research Indian Journal of Medical Research, Vol 138, Iss 1, Pp 60-67 (2013) |
| ISSN: | 0975-9174 0971-5916 |
| Popis: | Pre-eclampsia (PE) is a pregnancy related disorder characterized by hypertension and proteinuria noticeable after 20 wk of gestation. It is a leading cause of maternal and foetal mortality and morbidity worldwide. The aetiology of the disease is unknown, but recent studies have revealed that this disorder appears to originate in placenta and is characterized by widespread maternal endothelial dysfunction. Till date, delivery of placenta is the only cure for the disease. So, there is a need for the identification of highly specific and sensitive biochemical markers that would allow early identification of patients at risk and thus help in providing proper prenatal care. Several promising biomarkers have been proposed, alone or in combination, that may help in predicting women who are likely to develop PE. Maternal serum concentrations of these biomarkers either increase or decrease in PE during gestation. This review focuses on the various biomarkers available and their utility in predicting pre-eclampsia. |
| Databáze: | OpenAIRE |
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