Abnormal visuomotor processing in schizophrenia
| Autor: | Siân E. Robson, Matthew J. Brookes, Emma L. Hall, Lena Palaniyappan, Jyothika Kumar, Michael Skelton, Nikolaos G. Christodoulou, Ayaz Qureshi, Fiesal Jan, Mohammad Z. Katshu, Elizabeth B. Liddle, Peter F. Liddle, Peter G. Morris |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Cerebral Cortex Male genetic structures Magnetoencephalography Regular Article lcsh:Computer applications to medicine. Medical informatics behavioral disciplines and activities Brain Waves lcsh:RC346-429 Young Adult Schizophrenia Visual Perception lcsh:R858-859.7 Motor cortex Humans Female Schizophrenic Psychology Visual cortex Electrophysiological processes lcsh:Neurology. Diseases of the nervous system Photic Stimulation Psychomotor Performance |
| Zdroj: | NeuroImage : Clinical Brain and Mind Institute Researchers' Publications NeuroImage: Clinical, Vol 12, Iss C, Pp 869-878 (2016) |
| ISSN: | 2213-1582 |
| Popis: | Subtle disturbances of visual and motor function are known features of schizophrenia and can greatly impact quality of life; however, few studies investigate these abnormalities using simple visuomotor stimuli. In healthy people, electrophysiological data show that beta band oscillations in sensorimotor cortex decrease during movement execution (event-related beta desynchronisation (ERBD)), then increase above baseline for a short time after the movement (post-movement beta rebound (PMBR)); whilst in visual cortex, gamma oscillations are increased throughout stimulus presentation. In this study, we used a self-paced visuomotor paradigm and magnetoencephalography (MEG) to contrast these responses in patients with schizophrenia and control volunteers. We found significant reductions in the peak-to-peak change in amplitude from ERBD to PMBR in schizophrenia compared with controls. This effect was strongest in patients who made fewer movements, whereas beta was not modulated by movement in controls. There was no significant difference in the amplitude of visual gamma between patients and controls. These data demonstrate that clear abnormalities in basic sensorimotor processing in schizophrenia can be observed using a very simple MEG paradigm. Highlights • Visual and motor deficits in schizophrenia are rarely investigated. • We use MEG to non-invasively assess the neural basis of these deficits. • Patients showed abnormalities in neuronal oscillations in motor cortex. • Beta band power, reflecting cortical inhibition, was reduced after movements. • Increased movement frequency may be a behavioural compensation for this reduction. |
| Databáze: | OpenAIRE |
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