The Role of NK Cells in Pig-to-Human Xenotransplantation
| Autor: | Puga Yung, Gisella, Schneider, Mårten K. J., Seebach, Jörg D. |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
lcsh:Immunologic diseases. Allergy
Cytotoxicity Immunologic Graft Rejection Primates Swine Cytotoxicity T-Lymphocytes Transplantation Heterologous Genetically Modified Review Article Graft Rejection/immunology/prevention & control Immunotherapy Adoptive T-Lymphocytes Regulatory Cell Line Animals Genetically Modified Heterografts/immunology Immunologic HLA Antigens Dendritic Cells/immunology/transplantation Cell Adhesion Killer Cells Animals Humans ddc:616 Transplantation Heterologous Endothelial Cells/immunology Endothelial Cells HLA Antigens/genetics Dendritic Cells Genetic Therapy Killer Cells Natural Natural/immunology Adoptive/methods Heterografts Immunotherapy Regulatory/immunology/transplantation lcsh:RC581-607 |
| Zdroj: | Journal of Immunology Research Journal of Immunology Research, Vol 2017 (2017) Journal of Immunology Research, Vol. 2017 (2017) P. 4627384 |
| ISSN: | 2314-7156 2314-8861 |
| Popis: | Recruitment of human NK cells to porcine tissues has been demonstrated in pig organs perfused ex vivo with human blood in the early 1990s. Subsequently, the molecular mechanisms leading to adhesion and cytotoxicity in human NK cell-porcine endothelial cell (pEC) interactions have been elucidated in vitro to identify targets for therapeutic interventions. Specific molecular strategies to overcome human anti-pig NK cell responses include (1) blocking of the molecular events leading to recruitment (chemotaxis, adhesion, and transmigration), (2) expression of human MHC class I molecules on pECs that inhibit NK cells, and (3) elimination or blocking of pig ligands for activating human NK receptors. The potential of cell-based strategies including tolerogenic dendritic cells (DC) and regulatory T cells (Treg) and the latest progress using transgenic pigs genetically modified to reduce xenogeneic NK cell responses are discussed. Finally, we present the status of phenotypic and functional characterization of nonhuman primate (NHP) NK cells, essential for studying their role in xenograft rejection using preclinical pig-to-NHP models, and summarize key advances and important perspectives for future research. |
| Databáze: | OpenAIRE |
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