Mice exposed to diagnostic ultrasound in utero are less social and more active in social situations relative to controls
| Autor: | McClintic, Abbi M, King, Bryan H, Webb, Sara J, Mourad, Pierre D |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
Pediatric Research Initiative Autism Intellectual and Developmental Disabilities (IDD) autistic-like behavior Clinical Sciences Developmental & Child Psychology Reproductive health and childbirth Article Ultrasonography Prenatal Mice Pregnancy Risk Factors Behavioral and Social Science Prenatal Psychology Animals Humans mouse social behavior Social Behavior Ultrasonography Pediatric Behavior Behavior Animal Animal Neurosciences Perinatal Period - Conditions Originating in Perinatal Period Brain Disorders Mental Health risk factor Prenatal Exposure Delayed Effects Biomedical Imaging Female diagnostic ultrasound |
| Zdroj: | Autism research : official journal of the International Society for Autism Research, vol 7, iss 3 |
| Popis: | Clinical use of diagnostic ultrasound imaging during pregnancy has a long history of safety and diagnostic utility, as supported by numerous human case reports and epidemiological studies. However, there exist in vivo studies linking large but clinically relevant doses of ultrasound applied to mouse fetuses in utero to altered learning, memory, and neuroanatomy of those mice. Also, there exists a well-documented significant increase in the likelihood of non-right-handedness in boys exposed to diagnostic ultrasound in utero, potentially relevant given the increased prevalence of autism in males, and reports of excess non-right-handedness in this population. Motivated by these observations, we applied 30 minutes of diagnostic ultrasound to pregnant mice at embryonic day 14.5 and assayed the social behavior of their male pups 3 weeks after their birth. The ultrasound-exposed pups were significantly (P |
| Databáze: | OpenAIRE |
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