Anodal tDCS modulates cortical activity and synchronization in Parkinson's disease depending on motor processing
| Autor: | Anna, Schoellmann, Marlieke, Scholten, Barbara, Wasserka, Rathinaswamy B, Govindan, Rejko, Krüger, Alireza, Gharabaghi, Christian, Plewnia, Daniel, Weiss |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male therapy [Parkinson Disease] Parkinson's disease Electroencephalography Phase Synchronization atDCS anodal tDCS brain stimulation cortical Transcranial Direct Current Stimulation lcsh:Computer applications to medicine. Medical informatics PD Parkinson's disease physiology [Electroencephalography Phase Synchronization] lcsh:RC346-429 rmANOVA repeated measures analysis of variance Ag/AgCl silver/silver chloride physiopathology [Cerebral Cortex] Placebos Double-Blind Method M1 primary motor area FDI first dorsal interosseous muscle Humans ddc:610 HC healthy controls lcsh:Neurology. Diseases of the nervous system Aged Cerebral Cortex Parkinson Disease Regular Article tACS transcranial alternating current stimulation Signal Processing Computer-Assisted SM1 primary sensorimotor area tDCS transcranial direct current stimulation Middle Aged coherence UPDRS Unified Parkinson's disease rating scale APB abductor pollicis brevis muscle Treatment Outcome Motor Skills GABA gamma-aminobutyric acid lcsh:R858-859.7 Female physiopathology [Parkinson Disease] DBS deep brain stimulation MAD mean absolute deviation STN subthalamic nucleus physiology [Motor Skills] |
| Zdroj: | NeuroImage: Clinical, Vol 22, Iss, Pp-(2019) NeuroImage: Clinical 22, 101689 (2019). doi:10.1016/j.nicl.2019.101689 NeuroImage : Clinical |
| ISSN: | 2213-1582 |
| DOI: | 10.1016/j.nicl.2019.101689 |
| Popis: | Background Transcranial direct current stimulation (tDCS) may alleviate motor symptoms in Parkinson's disease (PD). However, the neurophysiological effects of tDCS on cortical activation, synchronization, and the relation to clinical motor symptoms and motor integration need characterization. Objective We aimed to explore the effect of tDCS over the left sensorimotor area on clinical motor outcome, right hand fine motor performance as well as cortical activity and synchronization in the high beta range. Methods In this double-blind randomized sham-controlled clinico-neurophysiological study we investigated ten idiopathic PD patients and eleven matched healthy controls (HC) on two days during an isometric precision grip task and at rest before and after ‘verum’ and ‘sham’ anodal tDCS (20 min; 1 mA; anode [C3], cathode [Fp2]). We measured clinical outcome, fine motor performance, and analysed both cortical frequency domain activity and corticocortical imaginary coherence. Results tDCS improved PD motor symptoms. Neurophysiological features indicated a motor-task-specific modulation of activity and coherence from 22 to 27 Hz after ‘verum’ stimulation in PD. Activity was significantly reduced over the left sensorimotor and right frontotemporal area. Before stimulation, PD patients showed reduced coherence over the left sensorimotor area during motor task compared to HC, and this increased after ‘verum’ stimulation in the motor task. The activity and synchronization modulation were neither observed at rest, after sham stimulation nor in healthy controls. Conclusion Verum tDCS modulated the PD cortical network specifically during fine motor integration. Cortical oscillatory features were not in general deregulated in PD, but depended on motor processing. Highlights • tDCS improved motor function in Parkinson's disease. • tDCS modulated cortical beta activity and synchronization in Parkinson's disease. • the Parkinson's disease motor network may be susceptible to cortical stimulation. • tDCS may reverse pathologic cortical network states. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|