Age-dependent changes of baroreflex efficiency in Dahl rats: effects of high salt intake

Autor:	J, Nedvídek, J, Zicha
Rok vydání:	1993
Předmět:	Male Aging Phenylephrine Genotype Heart Rate Animals Blood Pressure Rats Inbred Strains Sodium Dietary Sodium Chloride Baroreflex Rats
Zdroj:	Physiological research. 42(3)
ISSN:	0862-8408
Popis:	The age-dependent changes in baroreflex control of heart rate were studied in inbred Dahl rats. At the age of 8 weeks the baroreflex slope was significantly greater in salt-resistant (R/Jr) than in salt-sensitive (S/Jr) rats fed a low-salt diet. The reverse was true in 16-week-old animals. High salt intake (8% NaCl diet for 4 weeks) suppressed baroreflex efficiency in both age groups of S/Jr animals whereas no effects occurred in R/Jr rats. Baroreflex slope was, however, significantly lower in young S/Jr rats with a severe form of salt hypertension than in adult salt-loaded S/Jr rats in which only a moderate blood pressure elevation was observed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::917b07044ff7cd90f43d820a2af4beb1 https://pubmed.ncbi.nlm.nih.gov/8218156 Zobrazit plný text záznamu