Factors affecting successful mobilization with plerixafor: an Italian prospective survey in 215 patients with multiple myeloma and lymphoma
| Autor: | Lanza, F., Lemoli, R. M., Olivieri, A., Laszlo, D., Martino, M., Specchia, G., Pavone, V., Imola, M., Pasini, A., Milone, G., Scortechini, I., Todisco, E., Guggiari, E., Cascavilla, N., Martinelli, G., Rambaldi, A., Bosi, A. |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Benzylamines Receptors CXCR4 Adolescent Lymphoma Cyclams NO Aged Blood Component Removal Chemoradiotherapy Data Collection Female Hematopoietic Stem Cell Mobilization Heterocyclic Compounds Humans Italy Leukapheresis Middle Aged Multiple Myeloma Platelet Count Predictive Value of Tests Prospective Studies Young Adult Receptors CXCR4 |
| Popis: | Although the efficacy of plerixafor in peripheral blood stem cell (PBSC) mobilization has been explored in several studies, factors associated with successful plerixafor mobilization after administration of granulocyte-colony-stimulating factor (G-CSF), with or without chemotherapy, have not been investigated. We analyzed data on PBSC mobilization from a large Italian database of lymphoma and myeloma plerixafor-treated patients.Two endpoints were established to define successful mobilization: patients with at least 2 × 10(6) CD34+ cells/kg collected by three leukapheresis procedures and patients achieving a peak count of at least 20 × 10(6) CD34+ cells/L during mobilization.Plerixafor achieved successful mobilization in both predicted (n = 64) and proven poor mobilizers (PMs; n = 143), classified according to the Gruppo Italiano Trapianto di Midollo Osseo (GITMO) criteria. Successful mobilization was independent of type of mobilization (steady state or chemotherapy); age; sex; disease; number or type of chemotherapy regimens preceding plerixafor; radiation therapy; prior treatment with melphalan, carmustine, lenalidomide, and radioimmune conjugates; and laboratory variables. Multivariate analysis identified previous fludarabine treatment and premobilization platelet count as predictors of successful mobilization.This large, prospective, nationwide study confirmed plerixafor efficacy for mobilizing PBSCs when added to G-CSF with or without chemotherapy. Plerixafor can overcome negative effects of most predictors of poor mobilization to achieve satisfactory harvest both in predicted and proven PM. |
| Databáze: | OpenAIRE |
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