A putative human zinc-finger gene (ZFPL1) on 11q13, highly conserved in the mouse and expressed in exocrine pancreas. The European Consortium on MEN 1

Autor: J W, Höppener, M J, De Wit, A Y, Simarro-Doorten, J F, Roijers, H M, van Herrewaarden, C J, Lips, F, Parente, D, Quincey, P, Gaudray, S, Khodaei, G, Weber, B, Teh, F, Farnebo, C, Larsson, C X, Zhang, A, Calender, A A, Pannett, S A, Forbes, J H, Bassett, R V, Thakker, I, Lemmens, W J, Van de Ven, K, Kas
Jazyk: angličtina
Rok vydání: 1998
Předmět:
Zdroj: Genomics. 50(2)
ISSN: 1089-8646
0888-7543
Popis: In the process of identification of the multiple endocrine neoplasia type 1 gene, which was recently published, we isolated a novel gene in the 11q13 region. This gene (named ZFPL1, for zinc-finger protein-like 1) is expressed strongly in the exocrine pancreas as a 1.4-kb polyadenylated RNA encoding a putative protein of 310 amino acids. A mouse EST contig predicts an equally sized murine protein with 91% amino acid sequence identity to the human protein. No significant homology with known proteins could be found through database screening. However, zinc-finger-like domains and leucine-zipper-like motifs in the predicted ZFPL1 protein were identified, suggesting the presence of DNA-binding and dimerization domains possibly involved in transcription regulation. This notion is supported by the presence of a putative bipartite nuclear localization signal. This paper presents the full-length cDNA sequence for this gene, its genomic structure and chromosomal orientation, and expression studies by Northern blot hybridization and RNA in situ hybridization.
Databáze: OpenAIRE
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