Cutaneous pleomorphic T-cell lymphoma coexisting with myelodysplastic syndrome transforming into acute myeloid leukemia: successful treatment with a fludarabine-containing regimen
| Autor: | Breccia, M, Petti, Mc, D'Elia, Gm, D'Andrea, M, Carmosino, I, Alimena, Giuliana |
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| Rok vydání: | 2002 |
| Předmět: |
Male
Anemia Refractory with Excess of Blasts Skin Neoplasms Contraindications Remission Induction Cytarabine Neoplasms Second Primary primary myelodysplastic syndromes non Hodgkin's lymphoma acute myeloid leukemia FLAG regimen Immunophenotyping Lymphoma T-Cell Cutaneous Leukemia Myeloid Acute Methotrexate Bone Marrow Antineoplastic Combined Chemotherapy Protocols Granulocyte Colony-Stimulating Factor Disease Progression Humans Antineoplastic Agents Alkylating Vidarabine Aged |
| Zdroj: | European journal of haematology. 68(1) |
| ISSN: | 0902-4441 |
| Popis: | The coexistence of a primary myelodysplastic syndrome (MDS) and a T-cell cutaneous non-Hodgkin's lymphoma is an extremely rare event, which has so far only been reported in a single instance in the literature. We describe herein an additional case in which the lymphoid disease was combined with an MDS at the time of its evolution into acute myeloid leukemia (AML). Both diseases were successfully treated with a regimen containing fludarabine. We discuss possible pathogenetic mechanisms and suggest the use of nonalkylating drugs, such as fludarabine, for the treatment of this rare association of malignancies usually characterized by a very poor response to therapy. |
| Databáze: | OpenAIRE |
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