Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia
| Autor: | Turpin, Jocelyn, Yurick, David, Khoury, Georges, Pham, Hai, Locarnini, Stephen, Melamed, Anat, Witkover, Aviva, Wilson, Kim, Purcell, Damian, Bangham, Charles, Einsiedel, Lloyd |
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| Přispěvatelé: | Section of Virology, Division of Infectious Diseases, Imperial College, London, The Peter Doherty Institute for Infection and Immunity [Melbourne], University of Melbourne-The Royal Melbourne Hospital, Department of Microbiology and Immunology, University of Melbourne, Baker Heart and Diabetes Institute (AUSTRALIA), Alice Springs Hospital, Victorian Infectious Diseases Reference Laboratory, National Serological Reference Laboratory, Wellcome Trust |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male viruses HTLV-1/HBV coinfection [SDV]Life Sciences [q-bio] Immunology clonal expansion Microbiology Major Articles and Brief Reports Population Groups Proviruses immune system diseases oligoclonality hemic and lymphatic diseases CLINICAL ASSOCIATIONS Humans HTLV-1 INFECTION Lymphocytes 11 Medical and Health Sciences ComputingMilieux_MISCELLANEOUS Aged Aged 80 and over Human T-lymphotropic virus 1 Science & Technology Coinfection Australia virus diseases Middle Aged Viral Load 06 Biological Sciences Hepatitis B HTLV-I Infections PREVALENCE Infectious Diseases Viruses CELLS Female Life Sciences & Biomedicine Indigenous Australian population |
| Zdroj: | Journal of Infectious Diseases Journal of Infectious Diseases, Oxford University Press (OUP), 2019, 219 (4), pp.562-567. ⟨10.1093/infdis/jiy546⟩ The Journal of Infectious Diseases |
| ISSN: | 0022-1899 1537-6613 |
| DOI: | 10.1093/infdis/jiy546⟩ |
| Popis: | Human T-cell lymphotropic virus type 1 (HTLV-1) and hepatitis B virus coinfection is frequent in certain Indigenous Australian populations, but its outcome remains unknown. We report a higher degree of HTLV-1 clonal expansion than in those with HTLV-1 alone. The prevalence of human T-cell lymphotropic virus type 1 (HTLV-1) and hepatitis B virus (HBV) coinfection is high in certain Indigenous Australian populations, but its impact on HTLV-1 has not been described. We compared 2 groups of Indigenous adults infected with HTLV-1, either alone or coinfected with HBV. The 2 groups had a similar HTLV-1 proviral load, but there was a significant increase in clonal expansion of HTLV-1–infected lymphocytes in coinfected asymptomatic individuals. The degree of clonal expansion was correlated with the titer of HBV surface antigen. We conclude that HTLV-1/HBV coinfection may predispose to HTLV-1–associated malignant disease. |
| Databáze: | OpenAIRE |
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