Multivalent and multifunctional polysaccharide-based particles for controlled receptor recognition
| Autor: | Duan, Haohao, Donovan, Mark, Foucher, Aude, Schultze, Xavier, Lecommandoux, Sebastien |
|---|---|
| Přispěvatelé: | L'Oréal Recherche France (L'Oréal Recherche), L'OREAL, Laboratoire de Chimie des Polymères Organiques (LCPO), Centre National de la Recherche Scientifique (CNRS)-Institut Polytechnique de Bordeaux-Ecole Nationale Supérieure de Chimie, de Biologie et de Physique (ENSCBP)-Université de Bordeaux (UB)-Institut de Chimie du CNRS (INC), Team 3 LCPO : Polymer Self-Assembly & Life Sciences, Centre National de la Recherche Scientifique (CNRS)-Institut Polytechnique de Bordeaux-Ecole Nationale Supérieure de Chimie, de Biologie et de Physique (ENSCBP)-Université de Bordeaux (UB)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut Polytechnique de Bordeaux-Ecole Nationale Supérieure de Chimie, de Biologie et de Physique (ENSCBP)-Université de Bordeaux (UB)-Institut de Chimie du CNRS (INC) |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
lcsh:R
lcsh:Medicine [CHIM.THER]Chemical Sciences/Medicinal Chemistry Surface Plasmon Resonance Article Drug Delivery Systems Hyaluronan Receptors [CHIM.POLY]Chemical Sciences/Polymers Polyglutamic Acid Polysaccharides Humans lcsh:Q Lectins C-Type Hyaluronic Acid lcsh:Science Glucans Hydrophobic and Hydrophilic Interactions |
| Zdroj: | Scientific Reports Scientific Reports, Nature Publishing Group, 2018, 8 (1), pp.14730. ⟨10.1038/s41598-018-32994-y⟩ Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018) |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-018-32994-y⟩ |
| Popis: | International audience; Polysaccharides represent a versatile class of building blocks that are used in macromolecular design. By choosing the appropriate saccharide block, various physico-chemical and biological properties can be introduced both at the level of the polymer chains and the resulting self-assembled nanostructures. Here, we synthetized amphiphilic diblock copolymers combining a hydrophobic and helical poly(γ-benzyl-L-glutamate) PBLG and two polysaccharides, namely hyaluronic acid (HA) and laminarin (LAM). The copolymers could self-assemble to form particles in water by nanoprecipitation. In addition, hybrid particles containing both HA and LAM in different ratios were obtained by co-nanoprecipitation of the two copolymers. By controlling the self-assembly process, five particle samples with different morphologies and compositions were developed. The interaction between the particles and biologically relevant proteins for HA and LAM, namely CD44 and Dectin-1 respectively, was evaluated by surface plasmon resonance (SPR). We demonstrated that the particle-protein interaction could be modulated by the particle structure and composition. It is therefore suggested that this method based on nanoprecipitation is a practical and versatile way to obtain particles with controllable interactions with proteins, hence with the appropriate biological properties for biomedical applications such as drug delivery. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|