[A comparison of the efficacy of the anticlastogenic action of interferon and of the radiation-adaptive response]

Autor:	Gp, Makedonov, Ni, Alekhina, Leyla Tskhovrebova, Gd, Zasukhina
Rok vydání:	1993
Předmět:	Chromosome Aberrations Gamma Rays Mutation Humans Interferon-alpha Antimutagenic Agents Lymphocytes Cobalt Radioisotopes Adaptation Physiological Cells Cultured
Zdroj:	Europe PubMed Central
ISSN:	0033-8192
Popis:	Human lymphocytes, in the in vitro culture, exposed to X-rays (0.05 Gy) or treated with lymphoblastoid interferon (50 IE/ml) in phase G1 were less susceptible to induction of chromosome aberrations, of a chromosome type, by subsequent gamma-radiation (2 Gy) than those exposed to 2 Gy radiation only. The anticlastogenic effect of the pretreatment with interferon was considerably higher than that of preirradiation with X-rays which might be the result of the pleiotropic action of interferon in a cell.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::8d052a05ccc0395b082a7ca9678aac01 https://pubmed.ncbi.nlm.nih.gov/8502744 Zobrazit plný text záznamu