Heparin-binding protein in lower airway samples as a biomarker for pneumonia
| Autor: | Paulsson, Magnus, Thelaus, Louise, Riesbeck, Kristian, Qvarfordt, Ingemar, Smith, Margaretha E., Lindén, Anders, Linder, Adam |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Aged 80 and over Male Bronchoalveolar lavage Critical Care Assisted Ventilation RC705-779 Pneumonia Ventilator-Associated Blood Proteins Pneumonia Middle Aged Neutrophil Biology Respiration Artificial respiratory tract diseases Young Adult Diseases of the respiratory system Humans Female Letter to the Editor Bronchoalveolar Lavage Fluid Lung Biomarkers Aged Antimicrobial Cationic Peptides Retrospective Studies |
| Zdroj: | Respiratory Research, Vol 22, Iss 1, Pp 1-4 (2021) Respiratory Research |
| Popis: | Objectives Ventilator-associated pneumonia (VAP) is difficult to diagnose using clinical criteria and no biomarkers have yet been proved to be sufficiently accurate. The use of the neutrophil-derived Heparin-binding protein (HBP) as a biomarker for pneumonia was investigated in this exploratory case–control study in two intensive care units at a tertiary referral hospital. Methods Patients with clinical signs of pneumonia were recruited and bronchoalveolar lavage fluid (BALF) or bronchial wash (BW) samples were collected. Mechanically ventilated and lung healthy subjects were recruited as controls. HBP was measured with enzyme-linked immunosorbent assay. Results BALF was collected from 14 patients with pneumonia and 14 healthy controls. Median HBP in BALF pneumonia samples was 14,690 ng/ml and controls 16.2 ng/ml (p |
| Databáze: | OpenAIRE |
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