EPITHELIAL STEM CELL EXHAUSTION IN THE PATHOGENESIS OF IDIOPATHIC PULMONARY FIBROSIS

Autor:	Chilosi, M., Claudio DOGLIONI, Murer, B., Poletti, V.
Přispěvatelé:	Chilosi, M., Doglioni, Claudio, Murer, B., Poletti, V.
Jazyk:	angličtina
Rok vydání:	2010
Předmět:	Epithelial-Mesenchymal Transition senescence Stem Cells Apoptosis Epithelial Cells epithelial stem cell Fibroblasts Idiopathic Pulmonary Fibrosis Wnt Proteins Wnt-signalling-pathway IPF telomere dysfunction Animals Humans Lung Cellular Senescence Cell Proliferation Signal Transduction
Zdroj:	Scopus-Elsevier Europe PubMed Central
Popis:	New paradigms have been recently proposed in the pathogenesis of idiopathic pulmonary fibrosis (IPF), evidencing that in IPF the cumulative action of an accelerated parenchymal senescence determined by either telomere dysfunction or genetic defects, together with the concurrent noxious activity of tobacco smoking, are able to severely compromise the regenerative potential of parenchymal epithelial stem cells, triggering a cascade of molecular signals and events (scarring, bronchiolar proliferation, abnormal remodelling) eventually leading to severe and irreversible functional impairment. New pathogenic schemes focus on the complex molecular mechanisms driving in a vicious circle the different signalling pathways (e.g. Wnt/ -catenin, TGF-beta, caveolin-1, etc.) potentially involved in epithelial-mesenchymal transition and irreversible lung remodelling. (Sarcoidosis Vasc Diffuse Lung Dis 2010; 27: 7-18)
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::8aa86bb9ce90521f36a2b0b2f153dc31 http://hdl.handle.net/11562/345601 Zobrazit plný text záznamu