| Autor: |
Jenkins D, Ma, Penny, Uchigata Y, Kh, Jacobs, Ch, Mijovic, Hirata Y, Otani T, Fletcher J, Arthur Bradwell, Ah, Barnett |
| Předmět: |
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| Zdroj: |
Europe PubMed Central |
| Popis: |
Previous studies have shown that insulin-dependent diabetes mellitus is positively associated with HLA-DR4 and HLA-DR9 in Japanese populations. It was proposed that susceptibility to the disease is determined by a single HLA allele associated with both DR4 and DR9. DR genotypes in a Japanese population with insulin-dependent diabetes mellitus were determined by DRB/DQB RFLP analysis. A single disease-susceptibility-allele model was tested by the antigen-genotype-frequency-among-patients method. Recessive and additive inheritance of a single susceptibility allele were rejected. The DR9-associated disease-susceptibility allele in Japanese subjects is distinct from both the DR3- and DR4-associated susceptibility alleles in white Caucasians. The data suggest further complexity in the inheritance of HLA-associated susceptibility to insulin-dependent diabetes mellitus. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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