Very-low-carbohydrate diet enhances human T-cell immunity through immunometabolic reprogramming

Autor: Hirschberger, S., Strauß, G., Effinger, D., Marstaller, X., Ferstl, A., Müller, M.B., Wu, T., Hübner, M., Rahmel, T., Mascolo, H., Exner, N., Hess-Rieger, J., Kreth, F.W., Unger, K., Kreth, S.
Rok vydání: 2021
Předmět:
Zdroj: EMBO Molecular Medicine
EMBO Mol. Med.:e14323 (2021)
ISSN: 1757-4684
Popis: Very‐low‐carbohydrate diet triggers the endogenous production of ketone bodies as alternative energy substrates. There are as yet unproven assumptions that ketone bodies positively affect human immunity. We have investigated this topic in an in vitro model using primary human T cells and in an immuno‐nutritional intervention study enrolling healthy volunteers. We show that ketone bodies profoundly impact human T‐cell responses. CD4+, CD8+, and regulatory T‐cell capacity were markedly enhanced, and T memory cell formation was augmented. RNAseq and functional metabolic analyses revealed a fundamental immunometabolic reprogramming in response to ketones favoring mitochondrial oxidative metabolism. This confers superior respiratory reserve, cellular energy supply, and reactive oxygen species signaling. Our data suggest a very‐low‐carbohydrate diet as a clinical tool to improve human T‐cell immunity. Rethinking the value of nutrition and dietary interventions in modern medicine is required.
Ketogenic diet (KD) is characterized by a very limited uptake of carbohydrates, resulting in endogenous production of ketone bodies. This study identifies KD as a potent nutritional immunometabolic intervention to reprogram human T cell immunometabolism, favouring mitochondrial oxidative phosphorylation, thus enhancing both effector and regulatory T cell immune capacity and priming human T cells towards memory cell formation.
Databáze: OpenAIRE
Externí odkaz: