[The role of CD95 (APO-1/Fas) mutations in lymphoproliferative and malignant lymphatic diseases]

Autor:	Beltinger C, Böhler T, Schrappe M, Wd, Ludwig, Klaus-Michael Debatin
Předmět:	B-Lymphocytes Lymphoma T-Lymphocytes Apoptosis Precursor Cell Lymphoblastic Leukemia-Lymphoma Lymphoproliferative Disorders Autoimmune Diseases Mice Mutation Animals Humans fas Receptor Child Multiple Myeloma
Zdroj:	Europe PubMed Central
Popis:	CD95 (APO-1/Fas)-mediated apoptosis plays a major role in normal lymphocyte regulation. CD95 mutations cause a benign autoimmune lymphoproliferation syndrome (ALPS) in mice and humans. CD95 is mutated in some de novo T-lineage acute lymphoblastic leukemia of childhood and these mutations might be of biological significance. The resistance toward CD95-mediated apoptosis observed in most B-lineage ALL is not caused by mutations of CD95. CD95 mutations have been associated with Hodgkin's and Non-Hodgkin's lymphoma and have been described in multiple myeloma. The relevance of CD95 mutations for chemoresistance of ALL requires further study.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::87e16376fde175a0b4126b5b1d5748f7 http://europepmc.org/abstract/med/9743945 Zobrazit plný text záznamu