PSA-NCAM modulates BDNF-dependent survival and differentiation of cortical neurons

Autor:	Vutskits, Laszlo, Djebbara-Hannas, Z., Zhang, Huanxiang, Paccaud, Jean-Pierre, Durbec, Pascale, Rougon, G., Muller, Dominique, Kiss, Jozsef Zoltan
Rok vydání:	2001
Předmět:	Glycoside Hydrolases Cell Death/drug effects/physiology Cell Survival Recombinant Fusion Proteins Neural Cell Adhesion Molecule L1 urologic and male genital diseases Transfection Recombinant Fusion Proteins/genetics/metabolism Glycoside Hydrolases/metabolism Rats Sprague-Dawley Neurons/ cytology/metabolism Receptor trkB/metabolism Rhabdomyosarcoma Tumor Cells Cultured Animals Humans Receptor trkB Neural Cell Adhesion Molecules Cerebral Cortex Neurons Cell Death Signal Transduction/physiology Brain-Derived Neurotrophic Factor Cell Differentiation ddc:616.8 Rats nervous system Animals Newborn Brain-Derived Neurotrophic Factor/ pharmacology Sialic Acids Cell Differentiation/drug effects/physiology Sialic Acids/genetics/ metabolism/pharmacology Neural Cell Adhesion Molecules/genetics/ metabolism/pharmacology Cell Survival/drug effects/physiology Cerebral Cortex/ cytology Signal Transduction
Zdroj:	European Journal of Neuroscience, Vol. 13, No 7 (2001) pp. 1391-1402
ISSN:	0953-816X
Popis:	We show that the loss or inactivation of the polysialic acid (PSA) tail of neural cell adhesion molecule (NCAM) on rat cortical neurons in culture leads to reduced differentiation and survival. The mechanism by which this negative effect is mediated appears to involve the neuronal response to brain-derived neurotrophic factor (BDNF): (i) in the absence of PSA or in the presence of excess free PSA added to the culture medium, BDNF-induced cell signalling is reduced; (ii) the addition of exogenous BDNF to the medium reverses the effect of PSA loss or inactivation. These data suggest that PSA-NCAM, previously shown to modulate cell migration and plasticity, is needed for an adequate sensitivity of neurons to BDNF.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::87bd3814412cc216b3fe000ccf7ac966 https://pubmed.ncbi.nlm.nih.gov/11298800 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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