Resistance to activated protein C and factor V Leiden as risk factors for venous thrombosis

Autor:	Rm, Bertina, Ph, Reitsma, Fr, Rosendaal, Jan P Vandenbroucke
Rok vydání:	1995
Předmět:	Adult Male Factor V Environment Middle Aged Thrombophlebitis Disease-Free Survival Contraceptives Oral Hormonal Enzyme Activation Risk Factors Prevalence Humans Female Genetic Predisposition to Disease Partial Thromboplastin Time Factor V Deficiency Protein C
Zdroj:	Europe PubMed Central
ISSN:	0340-6245
Popis:	The recent discovery of the factor V Leiden mutation as the molecular defect in the large majority of APC-resistant individuals, has drastically changed our view on familial thrombophilia and it has contributed to a better understanding of the interaction of genetic and environmental risk factors. It has offered firm support for the view that venous thrombosis is a multifactorial disease and that the risk of thrombosis will increase as the number of genetic and/or environmental risk factors increases.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::869ffc506698bbc137f0dbd2392976ab https://pubmed.ncbi.nlm.nih.gov/8578504 Zobrazit plný text záznamu