Real-Time Dual-Wavelength Time-Resolved Diffuse Optical Tomography System for Functional Brain Imaging Based on Probe-Hosted Silicon Photomultipliers
| Autor: | Orive-Miguel, David, Sieno, Laura Di, Behera, Anurag, Ferocino, Edoardo, Contini, Davide, Condat, Laurent, Hervé, Lionel, Mars, Jérôme, Torricelli, Alessandro, Pifferi, Antonio, Mora, Alberto Dalla |
|---|---|
| Přispěvatelé: | Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information (CEA-LETI), Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), GIPSA - Signal Images Physique (GIPSA-SIGMAPHY), GIPSA Pôle Sciences des Données (GIPSA-PSD), Grenoble Images Parole Signal Automatique (GIPSA-lab), Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA)-Grenoble Images Parole Signal Automatique (GIPSA-lab), Université Grenoble Alpes (UGA), Dipartimento di Fisica [Politecnico Milano] (POLIMI), Politecnico di Milano [Milan] (POLIMI), King Abdullah University of Science and Technology (KAUST), Istituto di Fotonica e Nanotecnologie, Consiglio Nazionale delle Ricerche |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
[SDV.BIO]Life Sciences [q-bio]/Biotechnology
Phantoms Imaging [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging Functional Neuroimaging Spectrum Analysis Brain lcsh:Chemical technology Article time-correlated single-photon counting TheoryofComputation_MATHEMATICALLOGICANDFORMALLANGUAGES Humans Tomography Optical lcsh:TP1-1185 diffuse optical tomography [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing silicon photomultipliers functional imaging |
| Zdroj: | Sensors Sensors, 2020, Special Issue Scattering-Based Techniques for Sensing Applications, 20 (10), pp.2815. ⟨10.3390/s20102815⟩ Sensors, Vol 20, Iss 2815, p 2815 (2020) Sensors (Basel, Switzerland) Volume 20 Issue 10 |
| ISSN: | 1424-8220 |
| Popis: | Near-infrared diffuse optical tomography is a non-invasive photonics-based imaging technology suited to functional brain imaging applications. Recent developments have proved that it is possible to build a compact time-domain diffuse optical tomography system based on silicon photomultipliers (SiPM) detectors. The system presented in this paper was equipped with the same eight SiPM probe-hosted detectors, but was upgraded with six injection fibers to shine the sample at several points. Moreover, an automatic switch was included enabling a complete measurement to be performed in less than one second. Further, the system was provided with a dual-wavelength ( 670 n m and 820 n m ) light source to quantify the oxy- and deoxy-hemoglobin concentration evolution in the tissue. This novel system was challenged against a solid phantom experiment, and two in-vivo tests, namely arm occlusion and motor cortex brain activation. The results show that the tomographic system makes it possible to follow the evolution of brain activation over time with a 1 s -resolution. |
| Databáze: | OpenAIRE |
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