Short-interval intracortical inhibition: Comparison between conventional and threshold-tracking techniques

Autor: Gintaute Samusyte, Hugh Bostock, John Rothwell, Martin Koltzenburg
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Coefficient of repeatability
Adult
Male
Short-interval intracortical inhibition
Rest
Conditioning
Classical
Article
lcsh:RC321-571
rmANOVA
repeated measures analysis of variance
Random Allocation
Threshold-tracking TMS
Humans
A-SICI
short-interval intracortical inhibition obtained by conventional paradigm
lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry
Intraclass correlation coefficient
IQR
interquartile range
ICC
intraclass correlation coefficient
Electromyography
Motor Cortex
Reproducibility of Results
Neural Inhibition
Middle Aged
Reliability
Evoked Potentials
Motor
Transcranial Magnetic Stimulation
Healthy Volunteers
TA
T-SICI - A-SICI recording protocol sequence
TS1mV
test stimulus intensity to evoke a peak-to-peak MEP of 1 mV
MEP
motor evoked potential
Conditioning
Operant
Female
EMG
electromyography
T-SICI
short-interval intracortical inhibition obtained by threshold-tracking
CR
coefficient of repeatability
AT
A-SICI - T-SICI recording protocol sequence
Zdroj: Brain Stimulation
Brain Stimulation, Vol 11, Iss 4, Pp 806-817 (2018)
ISSN: 1876-4754
1935-861X
Popis: Background Short-interval intracortical inhibition (SICI) is conventionally measured as the relative amplitude reduction of motor evoked potentials (MEPs) by subthreshold conditioning stimuli. In threshold-tracking SICI (T-SICI), stimulus intensity is instead adjusted repeatedly to maintain a constant MEP and inhibition is measured as the relative threshold increase. T-SICI is emerging as a useful diagnostic test, but its relationship to conventional amplitude SICI (A-SICI) is unclear. Objective To compare T-SICI and its reliability with conventional A-SICI measurements. Methods In twelve healthy volunteers (6 men, median age 30 years), conventional and T-SICI were recorded at conditioning stimuli (CS) of 50–80% resting motor threshold (RMT) and interstimulus interval of 2.5 ms. Measurements were repeated on the same day and at least a week later by a single operator. Results Across the CS range, mean group T-SICI showed a strong linear relationship to the mean group values measured by conventional technique (y = 29.7–0.3x, R2 = 0.99), but there was considerable interindividual variability. At CS 60–80% RMT, T-SICI had excellent intraday (intraclass correlation coefficient, ICC, 0.81–0.92) and adequate-to-excellent interday (ICC 0.61–0.88) reproducibility. Conventional SICI took longer to complete (median of 5.8 vs 3.8 min, p
Highlights • Threshold-tracking SICI correlates well with conventional measures. • It shows a trend towards better reproducibility on a group level. • Threshold-tracking SICI is potentially quicker to obtain. • It may require a smaller sample size in interventional studies.
Databáze: OpenAIRE
Externí odkaz: