Metabolic Modifications by Common Respiratory Viruses and Their Potential as New Antiviral Targets
| Autor: | Jens, Kleinehr, Janine J, Wilden, Yvonne, Boergeling, Stephan, Ludwig, Eike R, Hrincius |
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| Přispěvatelé: | Universitäts- und Landesbibliothek Münster |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Rhinovirus
viruses Citric Acid Cycle Fatty Acids virus diseases Review Orthomyxoviridae Microbiology QR1-502 Adenoviridae Parainfluenza Virus 1 Human Respiratory Syncytial Viruses respiratory viruses metabolism host targeted antivirals Coronavirus Medicine and health Humans ddc:610 Energy Metabolism Glycolysis Respiratory Tract Infections |
| Zdroj: | Viruses, Vol 13, Iss 2068, p 2068 (2021) Viruses |
| Popis: | Respiratory viruses are known to be the most frequent causative mediators of lung infections in humans, bearing significant impact on the host cell signaling machinery due to their host-dependency for efficient replication. Certain cellular functions are actively induced by respiratory viruses for their own benefit. This includes metabolic pathways such as glycolysis, fatty acid synthesis (FAS) and the tricarboxylic acid (TCA) cycle, among others, which are modified during viral infections. Here, we summarize the current knowledge of metabolic pathway modifications mediated by the acute respiratory viruses respiratory syncytial virus (RSV), rhinovirus (RV), influenza virus (IV), parainfluenza virus (PIV), coronavirus (CoV) and adenovirus (AdV), and highlight potential targets and compounds for therapeutic approaches. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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