Contribution of damage-associated molecular patterns to transfusion-related acute lung injury in cardiac surgery
| Autor: | Müller, Marcella C.A., Tuinman, Pieter R., Vlaar, Alexander P., Tuip, Anita M., Maijoor, Kelly, Achouiti, Achmed, van t Veer, Cornelis, Vroom, Margreeth B., Juffermans, Nicole P. |
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| Přispěvatelé: | Intensive Care Medicine, Amsterdam Cardiovascular Sciences, Amsterdam institute for Infection and Immunity, Other departments, Infectious diseases, Center of Experimental and Molecular Medicine |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Aged
80 and over Male Respiratory Distress Syndrome Cardiopulmonary Bypass Acute Lung Injury Receptor for Advanced Glycation End Products S100 Proteins S100A12 Protein Pneumonia Ventilator-Associated Transfusion Reaction Original Articles Middle Aged Cytokines Humans Female Prospective Studies Cardiac Surgical Procedures HMGB1 Protein Receptors Immunologic Aged |
| Zdroj: | Blood transfusion, 12(3), 368-375. SIMTI SrL |
| ISSN: | 1723-2007 |
| Popis: | The incidence of transfusion-related acute lung injury (TRALI) in cardiac surgery patients is high and this condition contributes to an adverse outcome. Damage-associated molecular pattern (DAMP) molecules, HMGB1 and S100A12, are thought to mediate inflammatory changes in acute respiratory distress syndrome. We aimed to determine whether DAMP are involved in the pathogenesis of TRALI in cardiac surgery patients. This was a secondary analysis of a prospective observational trial in cardiac surgery patients admitted to the Intensive Care Unit of a university hospital in the Netherlands. Fourteen TRALI cases were randomly matched with 32 transfused and non-transfused controls. Pulmonary levels of HMGB1, S100A12 and inflammatory cytokines (interleukins-1β, -6, and -8 and tumour necrosis factor-α) were determined when TRALI evolved. In addition, systemic and pulmonary levels of soluble receptor for advanced glycation end products (sRAGE) were determined. HMGB1 expression and levels of sRAGE in TRALI patients did not differ from those in controls. There was a trend towards higher S100A12 levels in TRALI patients compared to the controls. Furthermore, S100A12 levels were associated with increased levels of markers of pulmonary inflammation, prolonged cardiopulmonary bypass, hypoxemia and duration of mechanical ventilation. No evidence was found that HMGB1 and sRAGE contribute to the development of TRALI. S100A12 is associated with duration of cardiopulmonary bypass, pulmonary inflammation, hypoxia and prolonged mechanical ventilation and may contribute to acute lung injury in cardiac surgery patients |
| Databáze: | OpenAIRE |
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