The role of epoxyeicosatrienoic acids in the cardiovascular system

Autor:	Yang, L, Mäki-Petäjä, K, Cheriyan, J, McEniery, C, Wilkinson, IB
Přispěvatelé:	Cheriyan, Joseph [0000-0001-6921-1592], McEniery, Carmel [0000-0003-3636-0705], Wilkinson, Ian [0000-0001-6598-9399], Apollo - University of Cambridge Repository
Jazyk:	angličtina
Rok vydání:	2015
Předmět:	Cardiovascular Physiological Phenomena soluble epoxide hydrolase inhibitor Cardiovascular Diseases Hydroxyeicosatetraenoic Acids cardiovascular system epoxyeicosatrienoic acids Reviews Animals Humans Molecular Targeted Therapy vascular tone health care economics and organizations
Zdroj:	British Journal of Clinical Pharmacology
ISSN:	1365-2125 0306-5251
Popis:	There is increasing evidence suggesting that epoxyeicosatrienoic acids (EETs) play an important role in cardioprotective mechanisms. These include regulating vascular tone, modulating inflammatory responses, improving cardiomyocyte function and reducing ischaemic damage, resulting in attenuation of animal models of cardiovascular risk factors. This review discusses the current knowledge on the role of EETs in endothelium-dependent control of vascular tone in the healthy and in subjects with cardiovascular risk factors, and considers the pharmacological potential of targeting this pathway.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::827f3921418def11ee37f2d04aacc1d7 http://europepmc.org/articles/PMC4500322 Zobrazit plný text záznamu Plný text