| Autor: |
Bakhram Iskenderov, On, Sisina, Sv, Saushkina, Lv, Kazantseva |
| Rok vydání: |
2012 |
| Předmět: |
|
| Zdroj: |
Europe PubMed Central |
| ISSN: |
0023-2149 |
| Popis: |
The influence of vascular remodeling and endothelial vasomotor function on the efficacy of indapamide retard was studied in 92 patients (49 men and 43 women) with stage I-II hypertensive disease and grade I-II arterial hypertension by observation of dynamics of the results of 24 hour AP monitoring and heart rhythm variability (HRV), cardio- and vasoprotective efects. The patients were divided into comparable groups. Group 1 was comprised of 40 patients without structural changes of the humeral artery (HA), group 2 included 52 patients undergoing HA remodeling. It was shown that antihypertensive efect of indapamide was virtually identical in both groups. Dynamics of left ventricular and HA structural/functional characteristics in group 2 was more pronounced than in group 1. Conversely, changes of spectral and time-dependent characteristics of HRV in group I were more significant than in group 2; they included suppression of reciprocal hyperactivity of the sympathetic nervous system. In the absence of structural vascular changes, the anti-hypertensive, cardio- and vasoprotective effects of indapamide retard were realized via neurohumoral blockade whereas direct vascular action of the drug prevailed in case of vascular remodeling and endothelial dysfunction |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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