| Autor: |
Avet-Loiseau H, Mc, Devilder, Garand R, Bouyge I, Mj, Rapp, Noel Milpied, Jl, Harousseau, Jp, Moisan, Bataille R |
| Rok vydání: |
1996 |
| Předmět: |
|
| Zdroj: |
Europe PubMed Central |
| ISSN: |
1078-0432 |
| Popis: |
Fluorescence in situ hybridization with a chromosome 12-specific alpha-centromeric probe and a 13q14 yeast artificial chromosome probe was performed on interphase cells from 100 patients with B-cell chronic lymphocytic leukemia. Thirty-one patients exhibited a 13q14 deletion. No correlation was found between 13q14 deletions and clinical stage, sex, or morphology. Sixteen patients had trisomy 12, including 6 (of 12) with an atypical morphology. Trisomy 12 and 13q14 abnormalities were detected concomitantly in three patients only. The analysis of patients with deletions clearly showed that in five cases a significant number of cells retained two signals with the yeast artificial chromosome probe, indicating a genetic heterogeneity among the leukemic population. Our data confirm that the 13q14 deletion is a frequent event, indicate that the concomitant occurrence of 13q14 deletion and trisomy 12 is rare but possible, and show that both abnormalities are secondary events in B-cell chronic lymphocytic leukemia. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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