Renal and intraglomerular haemodynamics in chronic heart failure with preserved and reduced ejection fraction
Autor: | Jung, Susanne, Bosch, Agnes, Kolwelter, Julie, Striepe, Kristina, Kannenkeril, Dennis, Schuster, Tizia, Ott, Christian, Achenbach, Stephan, Schmieder, Roland E. |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
Heart Failure
lcsh:Diseases of the circulatory (Cardiovascular) system Hemodynamics Stroke Volume Preserved ejection fraction urologic and male genital diseases Kidney Reduced ejection fraction lcsh:RC666-701 Original Research Articles Renal haemodynamics Cardiorenal interaction Humans ddc:610 Original Research Article Glomerular Filtration Rate |
Zdroj: | ESC Heart Failure ESC Heart Failure, Vol 8, Iss 2, Pp 1562-1570 (2021) |
ISSN: | 2055-5822 |
Popis: | Aims Congestive heart failure (CHF) and impaired renal function are two often co‐existing medical conditions and associated with adverse cardiovascular outcome. The aim of the current study was to assess renal and intraglomerular haemodynamics by constant infusion input clearance technique in subjects with CHF. Methods and results The group of subjects with CHF consisted of 27 individuals with HFpEF and 27 individuals with HFrEF and were compared with 31 healthy controls. Subjects underwent renal clearance examination to measure glomerular filtration rate (GFR) and renal blood and plasma flow (RBF and RPF) and to calculate intraglomerular haemodynamics such as resistances of the afferent (RA) and efferent arterioles (RE) as well as intraglomerular pressure (P glom). Measured GFR was lower in CHF subjects (68.1 ± 10.1 mL/min/1.73 m2) compared with controls (83.6 ± 13.4 mL/min/1.73 m2, P adj |
Databáze: | OpenAIRE |
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