[Tubulo-interstitial fibrosis: an emerging major health problem]
| Autor: | Julie, Klein, Mathieu, Miravete, Bénédicte, Buffin-Meyer, Joost P, Schanstra, Jean-Loup, Bascands |
|---|---|
| Přispěvatelé: | Institut de médecine moléculaire de Rangueil (I2MR), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées- Institut Fédératif de Recherche Bio-médicale Institution (IFR150)-Institut National de la Santé et de la Recherche Médicale (INSERM), Simon, Marie Francoise |
| Jazyk: | francouzština |
| Rok vydání: | 2011 |
| Předmět: |
Kallikrein-Kinin System
MESH: Cell Hypoxia Angiotensin-Converting Enzyme Inhibitors MESH: Extracellular Matrix Kidney urologic and male genital diseases Models Biological MESH: Lysophospholipids Myoblasts Renin-Angiotensin System Angiotensin Receptor Antagonists Mice MESH: Proteinuria MESH: Renin-Angiotensin System Animals Humans MESH: Animals MESH: Incidence MESH: Myoblasts MESH: Intercellular Signaling Peptides and Proteins MESH: Mice MESH: Cytokines MESH: Humans Incidence Macrophages MESH: Angiotensin-Converting Enzyme Inhibitors MESH: Models Biological MESH: Macrophages MESH: Kallikrein-Kinin System MESH: Kidney Fibroblasts MESH: Chemokines Cell Hypoxia Extracellular Matrix Proteinuria MESH: Angiotensin Receptor Antagonists MESH: Morbidity MESH: Kidney Failure Chronic MESH: Fibroblasts Disease Progression Cytokines Intercellular Signaling Peptides and Proteins Kidney Failure Chronic Nephritis Interstitial MESH: Disease Progression Chemokines Lysophospholipids Morbidity MESH: Nephritis Interstitial |
| Zdroj: | médecine/sciences médecine/sciences, 2011, 27 (1), pp.55-61. ⟨10.1051/medsci/201127155⟩ |
| ISSN: | 0767-0974 1958-5381 |
| DOI: | 10.1051/medsci/201127155⟩ |
| Popis: | International audience; The incidence of chronic kidney disease leading to end-stage renal disease has significantly increased and may reach epidemic proportions over the next decade. Regardless of the initial insult, the progression of most forms of renal disease results in tubulo-interstitial fibrosis. This has been closely correlated to the future appearance of renal failure and has therefore been associated with poor long-term prognosis. New molecules and agents to limit the development of tubulo-interstitial fibrosis and slow down the progression towards end-stage renal disease are needed. In the past twenty years, many efforts have been made to understand the mechanisms of tubulo-intersititial fibrosis with the final goal to develop new therapeutic strategies. In this context, this review will focus on the mechanisms and factors involved in the development and the progression of renal fibrosis and will discuss the new promising therapeutic strategies in animal and humans. |
| Databáze: | OpenAIRE |
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