Defining the surgical margins of adenoid cystic carcinoma and their impact on outcome: An international collaborative study
| Autor: | Amit, Moran, Na'ara, Shorook, Trejo-Leider, Leonor, Ramer, Naomi, Burstein, David, Yue, Ma, Miles, Brett, Yang, Xinjie, Lei, Delin, Bjoerndal, Kristine, Godballe, Christian, Mücke, Thomas, Wolff, Klaus-Dietrich, Eckardt, André M, Copelli, Chiara, Sesenna, Enrico, Patel, Snehal, Ganly, Ian, Gil, Ziv |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Adolescent Head and Neck Neoplasms/mortality salivary gland margins adenoid cystic carcinoma head and neck cancer oral cavity paranasal sinuses survival Disease-Free Survival Article Cohort Studies Young Adult Humans Aged Carcinoma Adenoid Cystic/mortality Aged 80 and over Margins of Excision Middle Aged Carcinoma Adenoid Cystic Survival Rate Treatment Outcome Head and Neck Neoplasms Female |
| Zdroj: | Amit, M, Na'ara, S, Trejo-Leider, L, Ramer, N, Burstein, D, Yue, M, Miles, B, Yang, X, Lei, D, Bjoerndal, K, Godballe, C, Mücke, T, Wolff, K-D, Eckardt, A M, Copelli, C, Sesenna, E, Patel, S, Ganly, I & Gil, Z 2017, ' Defining the surgical margins of adenoid cystic carcinoma and their impact on outcome : An international collaborative study ', Head & Neck (Print Edition), vol. 39, no. 5, pp. 1008-1014 . https://doi.org/10.1002/hed.24740 |
| DOI: | 10.1002/hed.24740 |
| Popis: | The mainstay of treatment in adenoid cystic carcinoma (ACC) of the head and neck is surgical resection with negative margins. The purpose of this study was to define the margin status that associates with survival outcomes of ACC of the head and neck.We conducted univariate and multivariate analyses of international data.Data of 507 patients with ACC of the head and neck were analyzed; negative margins defined as ≥5 mm were detected in 253 patients (50%). On multivariate analysis, the hazard ratios (HRs) of positive margin status were 2.68 (95% confidence interval [CI], 1.2-6.2; p = .04) and 2.63 (95% CI, 1.1-6.3; p = .03) for overall survival (OS) and disease-specific survival (DSS), respectively. Close margins had no significant impact on outcome, with HRs of 1.1 (95% CI, 0.4-3.0; p = .12) and 1.07 (95% CI, 0.3-3.4; p = .23) for OS and DSS, respectively, relative with negative margins.In head and neck ACC, positive margins are associated with the worst outcome. Negative or close margins are associated with improved outcome, regardless of the distance from the tumor. © 2017 Wiley Periodicals, Inc. Head Neck 39: 1008-1014, 2017. |
| Databáze: | OpenAIRE |
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