Cerebral metabolic responses to clomipramine are greatly reduced following pretreatment with the specific serotonin neurotoxin para-chloroamphetamine (PCA). A 2-deoxyglucose study in rats
| Autor: | U, Freo, P, Pietrini, G, Pizzolato, M, Furey, A, Merico, S, Ruggero, M, Dam, L, Battistin |
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| Přispěvatelé: | U., Freo, P., Pietrini, Pizzolato, Gilberto, M., Furey, A., Merico, S., Ruggero, M., Dam, L., Battistin |
| Jazyk: | angličtina |
| Rok vydání: | 1995 |
| Předmět: |
Male
administration /&/ dosage Serotonin Uptake Inhibitor Antidepressive Agents Tricyclic Deoxyglucose Animals Antidepressive Agents Tricyclic pharmacology Brain Chemistry Brain drug effects/metabolism Clomipramine pharmacology Deoxyglucose metabolism Energy Metabolism Male Rats Rats Inbred F344 Serotonin Agents administration /&/ dosage Serotonin Uptake Inhibitors pharmacology p-Chloroamphetamine administration /&/ dosage Serotonin Agents Animals Inbred F344 Serotonin Agent p-Chloroamphetamine Animals Antidepressive Agent Brain Chemistry Inbred F344 Brain Rats Inbred F344 Antidepressive Agents Rats metabolism Energy Metabolism Male Rats Rat Clomipramine Serotonin Uptake Inhibitors pharmacology drug effects/metabolism Energy Metabolism metabolism Selective Serotonin Reuptake Inhibitors |
| Popis: | To determine if reported reductions of regional cerebral metabolic rates for glucose (rCMRglc) induced by the tryciclic antidepressant clomipramine (CMI) (10 mg/kg) are due to a presynaptic action on serotonin (5-HT) terminals, 3-month-old Fischer-344 rats were given parachloroamphetamine (PCA), a serotonin neurotoxin. rCMRglc was measured 3 weeks later in 55 brain regions after the administration of saline or CMI using the quantitative autoradiographic [14C]2-deoxyglucose procedure. PCA alone increased rCMRglc in the visual cortex. CMI alone reduced rCMRglc in 18 (33\%) of the studied regions, including telencephalic, diencephalic, limbic, and brain stem areas. In PCA-lesioned rats, metabolic responses to CMI (10 mg/kg) were greatly reduced, and significant rCMRglc decreases were observed only in 4 (7\%) of the brain areas, including the hippocampus and raphe nuclei. Abolition by PCA of the metabolic responses to CMI confirms that CMI, at the dose studied, reduces rCMRglc via a presynaptic mechanism, likely the 5-HT reuptake sites. |
| Databáze: | OpenAIRE |
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