Identification of FBXL4 as a Metastasis Associated Gene in Prostate Cancer
| Autor: | Stankiewicz, Elzbieta, Mao, Xueying, Mangham, D. Chas, Xu, Lei, Yeste-Velasco, Marc, Fisher, Gabrielle, North, Bernard, Chaplin, Tracy, Young, Bryan, Wang, Yuqin, Kaur Bansal, Jasmin, Kudahetti, Sakunthala, Spencer, Lucy, Foster, Christopher S., Møller, Henrik, Scardino, Peter, Oliver, R. Tim, Shamash, Jonathan, Cuzick, Jack, Cooper, Colin S., Berney, Daniel M., Lu, Yong-Jie |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
Science Ubiquitin-Protein Ligases Gene Dosage Down-Regulation Bone Neoplasms Polymorphism Single Nucleotide Article Cell Movement Cell Line Tumor Lectins Journal Article Humans Genetic Predisposition to Disease Genetic Association Studies Neoplasm Staging Manchester Cancer Research Centre F-Box Proteins ResearchInstitutes_Networks_Beacons/mcrc Prostatic Neoplasms Prostate-Specific Antigen Neoplastic Cells Circulating Prognosis Survival Analysis Gene Expression Regulation Neoplastic Disease Progression Medicine Gene Deletion |
| Zdroj: | Stankiewicz, E, Mao, X, Mangham, D C, Xu, L, Yeste-Velasco, M, Fisher, G, North, B, Chaplin, T, Young, B, Wang, Y, Kaur Bansal, J, Kudahetti, S, Spencer, L, Foster, C S, Møller, H, Scardino, P, Oliver, R T, Shamash, J, Cuzick, J, Cooper, C S, Berney, D M & Lu, Y-J 2017, ' Identification of FBXL4 as a Metastasis Associated Gene in Prostate Cancer ', Scientific Reports, vol. 7, no. 1, 5124 . https://doi.org/10.1038/s41598-017-05209-z Stankiewicz, E, Mao, X, Mangham, D C, Xu, L, Yeste-velasco, M, Fisher, G, North, B, Chaplin, T, Young, B, Wang, Y, Kaur Bansal, J, Kudahetti, S, Spencer, L, Foster, C S, Møller, H, Scardino, P, Oliver, R T, Shamash, J, Cuzick, J, Cooper, C S, Berney, D M & Lu, Y 2017, ' Identification of FBXL4 as a Metastasis Associated Gene in Prostate Cancer ', Scientific Reports, vol. 7, no. 1 . https://doi.org/10.1038/s41598-017-05209-z Scientific Reports Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017) |
| Popis: | Prostate cancer is the most common cancer among western men, with a significant mortality and morbidity reported for advanced metastatic disease. Current understanding of metastatic disease is limited due to difficulty of sampling as prostate cancer mainly metastasizes to bone. By analysing prostate cancer bone metastases using high density microarrays, we found a common genomic copy number loss at 6q16.1–16.2, containing the FBXL4 gene, which was confirmed in larger series of bone metastases by fluorescence in situ hybridisation (FISH). Loss of FBXL4 was also detected in primary tumours and it was highly associated with prognostic factors including high Gleason score, clinical stage, prostate-specific antigen (PSA) and extent of disease, as well as poor patient survival, suggesting that FBXL4 loss contributes to prostate cancer progression. We also demonstrated that FBXL4 deletion is detectable in circulating tumour cells (CTCs), making it a potential prognostic biomarker by ‘liquid biopsy’. In vitro analysis showed that FBXL4 plays a role in regulating the migration and invasion of prostate cancer cells. FBXL4 potentially controls cancer metastasis through regulation of ERLEC1 levels. Therefore, FBXL4 could be a potential novel prostate cancer suppressor gene, which may prevent cancer progression and metastasis through controlling cell invasion. |
| Databáze: | OpenAIRE |
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