Fruit and vegetable intake and prostate cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)
| Autor: | Perez-Cornago, A, Travis, RC, Appleby, PN, Tsilidis, KK, Tjønneland, A, Olsen, A, Overvad, K, Katzke, V, Kühn, T, Trichopoulou, A, Peppa, E, Kritikou, M, Sieri, S, Palli, D, Sacerdote, C, Tumino, R, Bueno-de-Mesquita, HB, Agudo, A, Larrañaga, N, Molina-Portillo, E, Ardanaz, E, Chirlaque, M-D, Lasheras, C, Stattin, P, Wennberg, M, Drake, I, Malm, J, Schmidt, JA, Khaw, K-T, Gunter, M, Freisling, H, Huybrechts, I, Aune, D, Cross, AJ, Riboli, E, Key, TJ |
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| Přispěvatelé: | Imperial College Trust |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
Citrus Risk Assessment SDG 3 - Good Health and Well-being Risk Factors Surveys and Questionnaires Vegetables Journal Article Humans vegetable Oncology & Carcinogenesis Prospective Studies Life Style Aged Cancer och onkologi Incidence Prostatic Neoplasms fruit tumor subtypes Middle Aged prospective prostate cancer Diet Europe Fruit Cancer and Oncology 1112 Oncology And Carcinogenesis Cancer Epidemiology |
| Zdroj: | Perez-Cornago, A, Travis, R C, Appleby, P N, Tsilidis, K, Tjønneland, A, Olsen, A, Overvad, K, Katzke, V, Kühn, T, Trichopoulou, A, Peppa, E, Kritikou, M, Sieri, S, Palli, D, Sacerdote, C, Tumino, R, Bueno-De-Mesquita, B H, Agudo, A, Larranaga, N, Molina-Portillo, E, Ardanaz, E, Chirlaque, M-D, Lasheras, C, Stattin, P, Wennberg, M, Drake, I, Malm, J, Schmidt, J A, Khaw, K-T, Gunter, M, Freisling, H, Huybrechts, I, Aune, D, Cross, A J, Riboli, E & Key, T J 2017, ' Fruit and vegetable intake and prostate cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) ', International Journal of Cancer, vol. 141, no. 2, pp. 287-297 . https://doi.org/10.1002/ijc.30741 Perez-Cornago, A, Travis, R C, Appleby, P N, Tsilidis, K K, Tjonneland, A, Olsen, A, Overvad, K, Katzke, V, Kuhn, T, Trichopoulou, A, Peppa, E, Kritikou, M, Sieri, S, Palli, D, Sacerdote, C, Tumino, R, Bueno-de-Mesquita, H B A, Agudo, A, Larranaga, N, Molina-Portillo, E, Ardanaz, E, Chirlaque, M D, Lasheras, C, Stattin, P, Wennberg, M, Drake, I, Malm, J, Schmidt, J A, Khaw, K T, Gunter, M, Freisling, H, Huybrechts, I, Aune, D, Cross, A J, Riboli, E & Key, T J 2017, ' Fruit and vegetable intake and prostate cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) ', International Journal of Cancer, vol. 141, no. 2, pp. 287-297 . https://doi.org/10.1002/ijc.30741 International Journal of Cancer |
| DOI: | 10.1002/ijc.30741 |
| Popis: | Several dietary factors have been studied in relation to prostate cancer; however, most studies have not reported on subtypes of fruit and vegetables or tumor characteristics, and results obtained so far are inconclusive. This study aimed to examine the prospective association of total and subtypes of fruit and vegetable intake with the incidence of prostate cancer overall, by grade and stage of disease, and prostate cancer death. Lifestyle information for 142,239 men participating in the European Prospective Investigation into Cancer and Nutrition from 8 European countries was collected at baseline. Multivariable Cox regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). After an average follow‐up time of 13.9 years, 7,036 prostate cancer cases were identified. Compared with the lowest fifth, those in the highest fifth of total fruit intake had a significantly reduced prostate cancer risk (HR = 0.91; 95% CI = 0.83–0.99; p‐trend = 0.01). No associations between fruit subtypes and prostate cancer risk were observed, except for citrus fruits, where a significant trend was found (HR = 0.94; 95% CI = 0.86–1.02; p‐trend = 0.01). No associations between total and subtypes of vegetables and prostate cancer risk were observed. We found no evidence of heterogeneity in these associations by tumor grade and stage, with the exception of significant heterogeneity by tumor grade (p heterogeneity What's new? The role of diet in prostate‐cancer etiology is uncertain, and associations may vary by tumor characteristics. In this prospective, longitudinal study, the authors examined the association of total and subtypes of fruit and vegetable intake with the overall incidence of prostate cancer. They then analyzed incidence by grade, stage of disease, and prostate‐cancer death. They found that higher fruit intake was associated with a small reduction in prostate cancer risk, and that this association did not differ by tumor characteristics. |
| Databáze: | OpenAIRE |
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